Stephen E Girardin
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Explore the profile of Stephen E Girardin including associated specialties, affiliations and a list of published articles.
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174
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Recent Articles
31.
Lu Y, Zheng Y, Coyaud E, Zhang C, Selvabaskaran A, Yu Y, et al.
Science
. 2019 Oct;
366(6464):460-467.
PMID: 31649195
The nucleotide oligomerization domain (NOD)-like receptors 1 and 2 (NOD1/2) are intracellular pattern-recognition proteins that activate immune signaling pathways in response to peptidoglycans associated with microorganisms. Recruitment to bacteria-containing endosomes...
32.
Abdel-Nour M, Carneiro L, Downey J, Tsalikis J, Outlioua A, Prescott D, et al.
Science
. 2019 Jul;
365(6448).
PMID: 31273097
Multiple cytosolic innate sensors form large signalosomes after activation, but this assembly needs to be tightly regulated to avoid accumulation of misfolded aggregates. We found that the eIF2α kinase heme-regulated...
33.
Winsor N, Krustev C, Bruce J, Philpott D, Girardin S
Cell Microbiol
. 2019 Jul;
21(11):e13079.
PMID: 31265745
Inflammasomes are cytosolic, multimeric protein complexes capable of activating pro-inflammatory cytokines such as IL-1β and IL-18, which play a key role in host defence. Inflammasome components are highly expressed in...
34.
Lavagna A, Auger J, Dumesnil A, Roy D, Girardin S, Gisch N, et al.
Vet Res
. 2019 Jul;
50(1):52.
PMID: 31262357
Streptococcus suis serotype 2 is an important porcine pathogen and zoonotic agent causing sudden death, septic shock and meningitis, with exacerbated inflammation being a hallmark of the infection. A rapid,...
35.
Foerster E, Girardin S
Cell Host Microbe
. 2019 May;
25(5):632-634.
PMID: 31071290
In this issue of Cell Host & Microbe, Liang et al. (2019) show that α-defensins in the gastrointestinal tract sustain defenses to enteric pathogens during starvation. mTOR-dependent sensing of nutrient...
36.
Frirdich E, Biboy J, Pryjma M, Lee J, Huynh S, Parker C, et al.
Mol Microbiol
. 2019 May;
112(1):280-301.
PMID: 31070821
Campylobacter jejuni is a prevalent enteric pathogen that changes morphology from helical to coccoid under unfavorable conditions. Bacterial peptidoglycan maintains cell shape. As C. jejuni transformed from helical to coccoid,...
37.
Robertson S, Lemire P, Maughan H, Goethel A, Turpin W, Bedrani L, et al.
Cell Rep
. 2019 May;
27(6):1910-1919.e2.
PMID: 31067473
The intestinal microbiota is a fundamental factor that broadly influences physiology. Thus, studies using transgenic animals should be designed to limit the confounding effects of microbiota variation between strains. Here,...
38.
Molinaro R, Mukherjee T, Flick R, Philpott D, Girardin S
J Biol Chem
. 2019 Apr;
294(22):9007-9015.
PMID: 30996003
NOD1 and NOD2 are intracellular sensors of bacterial peptidoglycan that belong to the Nod-like receptor family of innate immune proteins. In addition to their role as direct bacterial sensors, it...
39.
Tsalikis J, Abdel-Nour M, Farahvash A, Sorbara M, Poon S, Philpott D, et al.
Mol Cell Biol
. 2019 Mar;
39(10).
PMID: 30910794
Protein degradation pathways are critical for maintaining proper protein dynamics within the cell, and considerable efforts have been made toward the development of therapeutics targeting these catabolic processes. We report...
40.
Scantlebery A, Uil M, Butter L, Poelman R, Claessen N, Girardin S, et al.
PLoS One
. 2019 Mar;
14(3):e0214437.
PMID: 30908533
Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus that results in both tubular and glomerular injury. Low-grade inflammation and oxidative stress are two mechanisms known to drive the...