Stephen D Fox
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Explore the profile of Stephen D Fox including associated specialties, affiliations and a list of published articles.
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30
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1263
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Recent Articles
1.
Abimannan T, Parthibane V, Le S, Vijaykrishna N, Fox S, Karim B, et al.
Sci Adv
. 2024 Apr;
10(17):eadk1045.
PMID: 38657065
T helper 17 (T17) cells are implicated in autoimmune diseases, and several metabolic processes are shown to be important for their development and function. In this study, we report an...
2.
Park J, Kirsch K, Lee H, Oliva P, Il Ahn J, Ravishankar H, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(35):e2305037120.
PMID: 37603740
Polo-like kinase 1 (Plk1) is considered an attractive target for anticancer therapy. Over the years, studies on the noncatalytic polo-box domain (PBD) of Plk1 have raised the expectation of generating...
3.
Link C, Thalalla Gamage S, Gallimore D, Kopajtich R, Evans C, Nance S, et al.
Biochemistry
. 2022 Mar;
61(7):535-544.
PMID: 35285626
Chemical modification of cytidine in noncoding RNAs plays a key role in regulating translation and disease. However, the distribution and dynamics of many of these modifications remain unknown due to...
4.
Shrimp J, Jing Y, Thalalla Gamage S, Nelson K, Han J, Bryson K, et al.
ACS Med Chem Lett
. 2021 Jun;
12(6):887-892.
PMID: 34141066
Remodelin is a putative small molecule inhibitor of the RNA acetyltransferase NAT10 which has shown preclinical efficacy in models of the premature aging disease Hutchinson-Gilford Progeria Syndrome (HGPS). Here we...
5.
Parthibane V, Lin J, Acharya D, Abimannan T, Srideshikan S, Klarmann K, et al.
J Biol Chem
. 2021 Mar;
296:100491.
PMID: 33662400
Serine palmitoyltransferase complex (SPT) mediates the first and rate-limiting step in the de novo sphingolipid biosynthetic pathway. The larger subunits SPTLC1 and SPTLC2/SPTLC3 together form the catalytic core while a...
6.
Kharat S, Ding X, Swaminathan D, Suresh A, Singh M, Sengodan S, et al.
Sci Signal
. 2020 Aug;
13(645).
PMID: 32817374
Synthetic lethality between poly(ADP-ribose) polymerase (PARP) inhibition and deficiency is exploited to treat breast and ovarian tumors. However, resistance to PARP inhibitors (PARPis) is common. To identify potential resistance mechanisms,...
7.
Howland R, Deziel N, Bentley G, Booth M, Choudhury O, Hofmann J, et al.
Int J Environ Res Public Health
. 2020 Feb;
17(4).
PMID: 32069802
Timing of breast development (or thelarche) and its endogenous and exogenous determinants may underlie global variation in breast cancer incidence. The study objectives were to characterize endogenous estrogen levels and...
8.
Levy M, Montgomery D, Sardiu M, Montano J, Bergholtz S, Nance K, et al.
Cell Chem Biol
. 2019 Dec;
27(3):322-333.e5.
PMID: 31836350
Acyl-coenzyme A (CoA)/protein interactions are essential for life. Despite this importance, their global scope and selectivity remains undefined. Here, we describe CATNIP (CoA/AcetylTraNsferase Interaction Profiling), a chemoproteomic platform for the...
9.
Parthibane V, Acharya D, Srideshikan S, Lin J, Myerscough D, Abimannan T, et al.
Blood Adv
. 2019 Nov;
3(22):3635-3649.
PMID: 31751474
Serine palmitoyltransferase (SPT) long-chain base subunit 1 (SPTLC1) is 1 of the 2 main catalytic subunits of the SPT complex, which catalyzes the first and rate-limiting step of sphingolipid biosynthesis....
10.
Issaq S, Mendoza A, Fox S, Helman L
Oncogenesis
. 2019 Feb;
8(3):20.
PMID: 30808861
Despite a growing body of knowledge about the genomic landscape and molecular pathogenesis of sarcomas, translation of basic discoveries into targeted therapies and significant clinical gains has remained elusive. Renewed...