Stephen D Bell
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Explore the profile of Stephen D Bell including associated specialties, affiliations and a list of published articles.
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97
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3364
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Recent Articles
11.
Takemata N, Bell S
J Cell Sci
. 2020 May;
133(10).
PMID: 32423947
Over the past decade, advances in methodologies for the determination of chromosome conformation have provided remarkable insight into the local and higher-order organization of bacterial and eukaryotic chromosomes. Locally folded...
12.
Takemata N, Samson R, Bell S
Cell
. 2019 Sep;
179(1):165-179.e18.
PMID: 31539494
The three-dimensional organization of chromosomes can have a profound impact on their replication and expression. The chromosomes of higher eukaryotes possess discrete compartments that are characterized by differing transcriptional activities....
13.
Samson R, Duggin I, Bell S
Methods Mol Biol
. 2019 Jun;
1998:1-11.
PMID: 31250290
Members of the archaeal domain of life that lack homologs of actin and tubulin divide by binary fission in a process that is dependent upon orthologs of eukaryotic ESCRT components....
14.
Bell S
Biochem Soc Trans
. 2019 Jan;
47(1):351-356.
PMID: 30647143
It has been known for decades that the principal replicative DNA polymerases that effect genome replication are incapable of starting DNA synthesis Rather, they require a 3'-OH group from which...
15.
Yan J, Holzer S, Pellegrini L, Bell S
Proc Natl Acad Sci U S A
. 2018 Jun;
115(26):6697-6702.
PMID: 29891690
The cellular replicative DNA polymerases cannot initiate DNA synthesis without a priming 3' OH. During DNA replication, this is supplied in the context of a short RNA primer molecule synthesized...
16.
Bell S
Adv Exp Med Biol
. 2018 Jan;
1042:99-115.
PMID: 29357055
Organisms within the archaeal domain of life possess a simplified version of the eukaryotic DNA replication machinery. While some archaea possess a bacterial-like mode of DNA replication with single origins...
17.
Holzer S, Yan J, Kilkenny M, Bell S, Pellegrini L
Nat Commun
. 2017 Nov;
8(1):1718.
PMID: 29167441
DNA replication depends on primase, the specialised polymerase responsible for synthesis of the RNA primers that are elongated by the replicative DNA polymerases. In eukaryotic and archaeal replication, primase is...
18.
Heimerl T, Flechsler J, Pickl C, Heinz V, Salecker B, Zweck J, et al.
Front Microbiol
. 2017 Jun;
8:1072.
PMID: 28659892
Based on serial sectioning, focused ion beam scanning electron microscopy (FIB/SEM), and electron tomography, we depict in detail the highly unusual anatomy of the marine hyperthermophilic crenarchaeon, . Our data...
19.
Samson R, Dobro M, Jensen G, Bell S
Subcell Biochem
. 2017 May;
84:357-377.
PMID: 28500532
Although morphologically resembling bacteria, archaea constitute a distinct domain of life with a closer affiliation to eukaryotes than to bacteria. This similarity is seen in the machineries for a number...
20.
Yan J, Beattie T, Rojas A, Schermerhorn K, Gristwood T, Trinidad J, et al.
Nat Commun
. 2017 May;
8:15075.
PMID: 28462924
Since their initial characterization over 30 years ago, it has been believed that the archaeal B-family DNA polymerases are single-subunit enzymes. This contrasts with the multi-subunit B-family replicative polymerases of...