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Adam T McGeoch

Explore the profile of Adam T McGeoch including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 266
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Recent Articles
1.
Barbour A, Sarov-Blat L, Cai G, Fossler M, Sprecher D, Graggaber J, et al.
Br J Clin Pharmacol . 2012 Dec; 76(1):99-106. PMID: 23215699
Aims: The purpose of this study was to establish safety and tolerability of a single intravenous (IV) infusion of a p38 mitogen-activated protein kinase inhibitor, losmapimod, to obtain therapeutic levels...
2.
McGeoch A, Bell S
Nat Rev Mol Cell Biol . 2008 Jun; 9(7):569-74. PMID: 18523437
DNA replication is fundamental to the propagation of cellular life. Remarkably, the bacterial replication machinery is distinct from that used by archaea and eukaryotes. In this article, we discuss the...
3.
Moreau M, McGeoch A, Lowe A, Itzhaki L, Bell S
Mol Cell . 2007 Oct; 28(2):304-14. PMID: 17964268
The subunits of the presumptive replicative helicase of archaea and eukaryotes, the MCM complex, are members of the AAA+ (ATPase-associated with various cellular activities) family of ATPases. Proteins within this...
4.
Barry E, McGeoch A, Kelman Z, Bell S
Nucleic Acids Res . 2007 Jan; 35(3):988-98. PMID: 17259218
The mini-chromosome maintenance (MCM) complex is the principal candidate for the replicative helicase of archaea and eukaryotes. Here, we describe a functional dissection of the roles of the three principal...
5.
Marsh V, McGeoch A, Bell S
J Mol Biol . 2006 Feb; 357(5):1345-50. PMID: 16490210
The mini-chromosome maintenance (MCM) complex is the presumptive replicative helicase in archaea and eukaryotes. In archaea, the MCM is a homo-multimer, in eukaryotes a heterohexamer composed of six related subunits,...
6.
McGeoch A, Trakselis M, Laskey R, Bell S
Nat Struct Mol Biol . 2005 Aug; 12(9):756-62. PMID: 16116441
The homomultimeric archaeal mini-chromosome maintenance (MCM) complex serves as a simple model for the analogous heterohexameric eukaryotic complex. Here we investigate the organization and orientation of the MCM complex of...
7.
McGeoch A, Bell S
Cell . 2005 Feb; 120(2):167-8. PMID: 15680323
No abstract available.