Stephen C Kowalczykowski
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Explore the profile of Stephen C Kowalczykowski including associated specialties, affiliations and a list of published articles.
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97
Citations
7319
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Recent Articles
1.
Gilhooly N, Kowalczykowski S
Biophys Rep (N Y)
. 2024 Feb;
4(1):100144.
PMID: 38390466
Single-molecule and bulk biophysical approaches to study protein-DNA interactions on surface-immobilized nucleic acid templates typically rely on modifying the ends of linear DNA molecules to enable surface-DNA attachments. Unless both...
2.
Pavankumar T, Wong C, Wong Y, Spies M, Kowalczykowski S
Nucleic Acids Res
. 2024 Jan;
52(5):2578-2589.
PMID: 38261972
The loading of RecA onto ssDNA by RecBCD is an essential step of RecBCD-mediated homologous recombination. RecBCD facilitates RecA-loading onto ssDNA in a χ-dependent manner via its RecB nuclease domain...
3.
Bell J, Dombrowski C, Plank J, Jensen R, Kowalczykowski S
Proc Natl Acad Sci U S A
. 2023 Mar;
120(14):e2221971120.
PMID: 36976771
Mutations in the breast cancer susceptibility gene, , greatly increase an individual's lifetime risk of developing breast and ovarian cancers. suppresses tumor formation by potentiating DNA repair via homologous recombination....
4.
Hertzog M, Perry T, Dupaigne P, Serres S, Morales V, Soulet A, et al.
Nucleic Acids Res
. 2023 Feb;
51(6):2800-2817.
PMID: 36806960
RecA-mediated homologous recombination (HR) is a key mechanism for genome maintenance and plasticity in bacteria. It proceeds through RecA assembly into a dynamic filament on ssDNA, the presynaptic filament, which...
5.
Tuan P, Gilhooly N, Marians K, Kowalczykowski S
Proc Natl Acad Sci U S A
. 2022 Sep;
119(39):e2208390119.
PMID: 36122225
In bacterial cells, DNA damage tolerance is manifested by the action of translesion DNA polymerases that can synthesize DNA across template lesions that typically block the replicative DNA polymerase III....
6.
West S, Kowalczykowski S
Proc Natl Acad Sci U S A
. 2021 Jan;
118(6).
PMID: 33495365
No abstract available.
7.
Jenkins S, Gore S, Guo X, Liu J, Ede C, Veaute X, et al.
Genetics
. 2019 May;
212(4):1133-1145.
PMID: 31142613
Srs2, in addition to its well-documented antirecombination activity, has been proposed to play a role in promoting synthesis-dependent strand annealing (SDSA). Here we report the identification and characterization of an...
8.
Graham J, Marians K, Kowalczykowski S
Cell
. 2017 Jun;
169(7):1201-1213.e17.
PMID: 28622507
It has been assumed that DNA synthesis by the leading- and lagging-strand polymerases in the replisome must be coordinated to avoid the formation of significant gaps in the nascent strands....
9.
Gong Y, Handa N, Kowalczykowski S, de Lange T
Genes Dev
. 2017 Jan;
31(1):46-58.
PMID: 28115467
Resection of double-strand breaks (DSBs) plays a critical role in their detection and appropriate repair. The 3' ssDNA protrusion formed through resection activates the ATR-dependent DNA damage response (DDR) and...
10.
Bell J, Kowalczykowski S
Trends Biochem Sci
. 2016 Jun;
41(7):646.
PMID: 27283513
No abstract available.