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Jason C Bell

Explore the profile of Jason C Bell including associated specialties, affiliations and a list of published articles. Areas
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Articles 15
Citations 1001
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Recent Articles
1.
Bell J, Dombrowski C, Plank J, Jensen R, Kowalczykowski S
Proc Natl Acad Sci U S A . 2023 Mar; 120(14):e2221971120. PMID: 36976771
Mutations in the breast cancer susceptibility gene, , greatly increase an individual's lifetime risk of developing breast and ovarian cancers. suppresses tumor formation by potentiating DNA repair via homologous recombination....
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Hertzog M, Perry T, Dupaigne P, Serres S, Morales V, Soulet A, et al.
Nucleic Acids Res . 2023 Feb; 51(6):2800-2817. PMID: 36806960
RecA-mediated homologous recombination (HR) is a key mechanism for genome maintenance and plasticity in bacteria. It proceeds through RecA assembly into a dynamic filament on ssDNA, the presynaptic filament, which...
3.
Satpathy A, Granja J, Yost K, Qi Y, Meschi F, McDermott G, et al.
Nat Biotechnol . 2019 Aug; 37(8):925-936. PMID: 31375813
Understanding complex tissues requires single-cell deconstruction of gene regulation with precision and scale. Here, we assess the performance of a massively parallel droplet-based method for mapping transposase-accessible chromatin in single...
4.
Jukam D, Limouse C, Smith O, Risca V, Bell J, Straight A
Curr Protoc Mol Biol . 2019 Feb; 126(1):e87. PMID: 30786161
RNA is a fundamental component of chromatin. Noncoding RNAs (ncRNAs) can associate with chromatin to influence gene expression and chromatin state; many also act at long distances from their transcriptional...
5.
Zhou X, Rodriguez-Rivera F, Lim H, Bell J, Bernhardt T, Bertozzi C, et al.
Nat Chem Biol . 2019 Jan; 15(3):221-231. PMID: 30664686
Members of the Corynebacterineae, including Corynebacterium and Mycobacterium, have an atypical cell envelope characterized by an additional mycomembrane outside of the peptidoglycan layer. How this multilayered cell envelope is assembled...
6.
Bell J, Jukam D, Teran N, Risca V, Smith O, Johnson W, et al.
Elife . 2018 Apr; 7. PMID: 29648534
RNA is a critical component of chromatin in eukaryotes, both as a product of transcription, and as an essential constituent of ribonucleoprotein complexes that regulate both local and global chromatin...
7.
Limouse C, Bell J, Fuller C, Straight A, Mabuchi H
Biophys J . 2018 Apr; 114(7):1539-1550. PMID: 29642025
Few techniques are suited to probe the structure and dynamics of molecular complexes at the mesoscale level (∼100-1000 nm). We have developed a single-molecule technique that uses tracking fluorescence correlation...
8.
Johnson W, Yewdell W, Bell J, McNulty S, Duda Z, ONeill R, et al.
Elife . 2017 Aug; 6. PMID: 28760200
Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear. Here, we...
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Bell J, Kowalczykowski S
Trends Biochem Sci . 2016 May; 41(6):491-507. PMID: 27156117
Homologous recombination maintains genomic integrity by repairing broken chromosomes. The broken chromosome is partially resected to produce single-stranded DNA (ssDNA) that is used to search for homologous double-stranded DNA (dsDNA)....