Mark S Dillingham
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Explore the profile of Mark S Dillingham including associated specialties, affiliations and a list of published articles.
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57
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2669
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Recent Articles
1.
Ballisat L, De Sio C, Beck L, Chambers A, Dillingham M, Guatelli S, et al.
Phys Med
. 2024 Dec;
129():104871.
PMID: 39667143
Purpose: Understanding cell cycle variations in radiosensitivity is important for α-particle therapies. Differences are due to both repair response mechanisms and the quantity of initial radiation-induced DNA strand breaks. Genome...
2.
De Braganca S, Dillingham M, Moreno-Herrero F
Trends Genet
. 2023 Oct;
39(12):924-940.
PMID: 37806853
Genome integrity and maintenance are essential for the viability of all organisms. A wide variety of DNA damage types have been described, but double-strand breaks (DSBs) stand out as one...
3.
Wilkinson M, Wilkinson O, Feyerherm C, Fletcher E, Wigley D, Dillingham M
Elife
. 2022 Dec;
11.
PMID: 36533901
Following infection of bacterial cells, bacteriophage modulate double-stranded DNA break repair pathways to protect themselves from host immunity systems and prioritise their own recombinases. Here, we present biochemical and structural...
4.
Aicart-Ramos C, Hormeno S, Wilkinson O, Dillingham M, Moreno-Herrero F
Methods Enzymol
. 2022 Aug;
673:311-358.
PMID: 35965011
Single molecule biophysics experiments for the study of DNA-protein interactions usually require production of a homogeneous population of long DNA molecules with controlled sequence content and/or internal tertiary structures. Traditionally,...
5.
Stevens E, Morse D, Bonini D, Duggan S, Brignoli T, Recker M, et al.
Microb Genom
. 2022 Apr;
8(4).
PMID: 35416147
is a major human pathogen that can cause severe invasive diseases such as pneumonia, septicaemia and meningitis. Young children are at a particularly high risk, with an estimated 3-4 million...
6.
Hormeno S, Wilkinson O, Aicart-Ramos C, Kuppa S, Antony E, Dillingham M, et al.
Proc Natl Acad Sci U S A
. 2022 Apr;
119(15):e2112376119.
PMID: 35385349
Human DNA helicase B (HELB) is a poorly characterized helicase suggested to play both positive and negative regulatory roles in DNA replication and recombination. In this work, we used bulk...
7.
Urrutia-Irazabal I, Ault J, Sobott F, Savery N, Dillingham M
Elife
. 2021 Jul;
10.
PMID: 34279225
The PcrA/UvrD helicase binds directly to RNA polymerase (RNAP) but the structural basis for this interaction and its functional significance have remained unclear. In this work, we used biochemical assays...
8.
Kuster A, Mozaffari N, Wilkinson O, Wojtaszek J, Zurfluh C, Przetocka S, et al.
Sci Adv
. 2021 Feb;
7(8).
PMID: 33608267
Cancer cells display high levels of DNA damage and replication stress, vulnerabilities that could be exploited by drugs targeting DNA repair proteins. Human CtIP promotes homology-mediated repair of DNA double-strand...
9.
Allen W, Watkins D, Dillingham M, Collinson I
Proc Natl Acad Sci U S A
. 2020 Dec;
117(50):31808-31816.
PMID: 33257538
The universally conserved Sec system is the primary method cells utilize to transport proteins across membranes. Until recently, measuring the activity-a prerequisite for understanding how biological systems work-has been limited...
10.
Wilkinson O, Carrasco C, Aicart-Ramos C, Moreno-Herrero F, Dillingham M
Nucleic Acids Res
. 2020 Jul;
48(14):7991-8005.
PMID: 32621607
DNA2 is an essential enzyme involved in DNA replication and repair in eukaryotes. In a search for homologues of this protein, we identified and characterised Geobacillus stearothermophilus Bad, a bacterial...