Stephane Ciblat
Overview
Explore the profile of Stephane Ciblat including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
152
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Recent Articles
1.
Cyr P, Fader L, Burch J, Pike K, Sietsema D, Boily M, et al.
ACS Med Chem Lett
. 2024 Dec;
15(12):2201-2209.
PMID: 39691514
Using a high-throughput screening (HTS) approach, a new GTP-site binding pyridine-carboxylate series of cGAS inhibitors was discovered. The biochemical potency of this new pyridine carboxylate series was improved 166-fold from...
2.
Terrett J, Ly J, Katavolos P, Hasselgren C, Laing S, Zhong F, et al.
J Med Chem
. 2024 Mar;
67(5):3287-3306.
PMID: 38431835
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium ion channel highly expressed in the primary sensory neurons, functioning as a polymodal sensor for exogenous and endogenous stimuli, and...
3.
Bubenik M, Mader P, Mochirian P, Vallee F, Clark J, Truchon J, et al.
J Med Chem
. 2022 Sep;
65(19):13198-13215.
PMID: 36126059
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead...
4.
Narayanan S, Dai D, Vyas Devambatla R, Albert V, Bruneau-Latour N, Vasukuttan V, et al.
Bioorg Med Chem
. 2022 May;
66:116789.
PMID: 35594649
The apelin receptor (APJ) is a target for cardiovascular indications. Previously, we had identified a novel pyrazole-based agonist 1 ((S)-N-(1-(cyclobutylamino)-1-oxo-5-(piperidin-1-yl)pentan-3-yl)-1-cyclopentyl-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxamide hydrochloride) of this GPCR. Systematic modification of 1 was performed...
5.
Marineau J, Hamman K, Hu S, Alnemy S, Mihalich J, Kabro A, et al.
J Med Chem
. 2021 Nov;
65(2):1458-1480.
PMID: 34726887
CDK7 has emerged as an exciting target in oncology due to its roles in two important processes that are misregulated in cancer cells: cell cycle and transcription. This report describes...
6.
Terrett J, Chen H, Shore D, Villemure E, Larouche-Gauthier R, Dery M, et al.
J Med Chem
. 2021 Mar;
64(7):3843-3869.
PMID: 33749283
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium-permeable ion channel highly expressed in the primary sensory neurons functioning as a polymodal sensor for exogenous and endogenous stimuli and...
7.
Hu S, Marineau J, Rajagopal N, Hamman K, Choi Y, Schmidt D, et al.
Cancer Res
. 2019 May;
79(13):3479-3491.
PMID: 31064851
Recent studies suggest that targeting transcriptional machinery can lead to potent and selective anticancer effects in cancers dependent on high and constant expression of certain transcription factors for growth and...
8.
Cooper A, Ciblat S, Shipps G, Levine J, Kostura M, Oza V, et al.
Bioorg Med Chem Lett
. 2018 Feb;
28(5):985.
PMID: 29433931
No abstract available.
9.
Cooper A, Ciblat S, Shipps G, Levine J, Kostura M, Oza V, et al.
Bioorg Med Chem Lett
. 2017 Aug;
27(18):4471-4477.
PMID: 28844391
A class of substituted 1-thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives was found to have potent anti-proliferative activity against a broad range of tumor cell lines. A compound from this class (14) was profiled...
10.
Tanaka K, Dietrich E, Ciblat S, Metayer C, Arhin F, Sarmiento I, et al.
Bioorg Med Chem Lett
. 2010 Jan;
20(4):1355-9.
PMID: 20097069
As therapeutic agents of choice in the treatment of complicated infections, glycopeptide antibiotics are often preferentially used in cases of osteomyelitis, an infection located in bone and notoriously difficult to...