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Lea Constantineau-Forget

Explore the profile of Lea Constantineau-Forget including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 35
Followers 0
Related Specialties
Chemistry
Biochemistry
Top 10 Co-Authors
Chantal Grand-Maitre
Martin Dery
Stephane Ciblat
Andre B Charette
Hank La
Jedd Levine
Yong Chen
Kang-Jye Chou
Kevin Johnson
Gerald Shipps
Published In
Bioorg Med Chem Lett
J Med Chem
Chem Commun (Camb)
J Org Chem
Affiliations
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Recent Articles
1.
Discovery of TRPA1 Antagonist : Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease
Terrett J, Ly J, Katavolos P, Hasselgren C, Laing S, Zhong F, et al.
J Med Chem . 2024 Mar; 67(5):3287-3306. PMID: 38431835
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium ion channel highly expressed in the primary sensory neurons, functioning as a polymodal sensor for exogenous and endogenous stimuli, and...
2.
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy
Terrett J, Chen H, Shore D, Villemure E, Larouche-Gauthier R, Dery M, et al.
J Med Chem . 2021 Mar; 64(7):3843-3869. PMID: 33749283
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium-permeable ion channel highly expressed in the primary sensory neurons functioning as a polymodal sensor for exogenous and endogenous stimuli and...
3.
Corrigendum to "1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents" [Bioorg. Med. Chem. Lett. 27 (2017) 4471-4477]
Cooper A, Ciblat S, Shipps G, Levine J, Kostura M, Oza V, et al.
Bioorg Med Chem Lett . 2018 Feb; 28(5):985. PMID: 29433931
No abstract available.
4.
1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents
Cooper A, Ciblat S, Shipps G, Levine J, Kostura M, Oza V, et al.
Bioorg Med Chem Lett . 2017 Aug; 27(18):4471-4477. PMID: 28844391
A class of substituted 1-thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives was found to have potent anti-proliferative activity against a broad range of tumor cell lines. A compound from this class (14) was profiled...
5.
General C-H Arylation Strategy for the Synthesis of Tunable Visible Light-Emitting Benzo[a]imidazo[2,1,5-c,d]indolizine Fluorophores
Levesque E, Bechara W, Constantineau-Forget L, Pelletier G, Rachel N, Pelletier J, et al.
J Org Chem . 2017 Apr; 82(10):5046-5067. PMID: 28441020
Herein we report the discovery of the benzo[a]imidazo[2,1,5-c,d]indolizine motif displaying tunable emission covering most of the visible spectrum. The polycyclic core is obtained from readily available amides via a chemoselective...
6.
Directed functionalization of 1,2-dihydropyridines: stereoselective synthesis of 2,6-disubstituted piperidines
Pelletier G, Constantineau-Forget L, Charette A
Chem Commun (Camb) . 2014 May; 50(52):6883-5. PMID: 24836467
A practical and highly stereoselective approach to access 2,6-disubstituted piperidines using an amidine auxiliary is reported. Following the diastereoselective addition of Grignard reagents at the 2-position of an activated pyridinium...
7.
Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus
Decor A, Grand-Maitre C, Hucke O, OMeara J, Kuhn C, Constantineau-Forget L, et al.
Bioorg Med Chem Lett . 2013 Jun; 23(13):3841-7. PMID: 23726345
We describe here the design, synthesis and biological evaluation of antiviral compounds acting against human rhinovirus (HRV). A series of aminothiazoles demonstrated pan-activity against the HRV genotypes screened and productive...