Steffen E Storck
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Explore the profile of Steffen E Storck including associated specialties, affiliations and a list of published articles.
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20
Citations
675
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Recent Articles
1.
Du S, Drieu A, Cheng Y, Storck S, Rustenhoven J, Mamuladze T, et al.
bioRxiv
. 2024 Aug;
PMID: 39211090
Microglia are thought to originate exclusively from primitive macrophage progenitors in the yolk sac (YS) and to persist throughout life without much contribution from definitive hematopoiesis. Here, using lineage tracing,...
2.
Smyth L, Xu D, Okar S, Dykstra T, Rustenhoven J, Papadopoulos Z, et al.
Nature
. 2024 Feb;
627(8002):165-173.
PMID: 38326613
The arachnoid barrier delineates the border between the central nervous system and dura mater. Although the arachnoid barrier creates a partition, communication between the central nervous system and the dura...
3.
Rustenhoven J, Pavlou G, Storck S, Dykstra T, Du S, Wan Z, et al.
J Exp Med
. 2023 Apr;
220(7).
PMID: 37027179
The meningeal lymphatic network enables the drainage of cerebrospinal fluid (CSF) and facilitates the removal of central nervous system (CNS) waste. During aging and in Alzheimer's disease, impaired meningeal lymphatic...
4.
Drieu A, Du S, Storck S, Rustenhoven J, Papadopoulos Z, Dykstra T, et al.
Nature
. 2022 Nov;
611(7936):585-593.
PMID: 36352225
Macrophages are important players in the maintenance of tissue homeostasis. Perivascular and leptomeningeal macrophages reside near the central nervous system (CNS) parenchyma, and their role in CNS physiology has not...
5.
Mazura A, Ohler A, Storck S, Kurtyka M, Scharfenberg F, Weggen S, et al.
Cell Mol Life Sci
. 2022 Mar;
79(4):212.
PMID: 35344086
Despite the neurodegenerative disorder Alzheimer's disease (AD) is the most common form of dementia in late adult life, there is currently no therapy available to prevent the onset or slow...
6.
Marengo L, Armbrust F, Schoenherr C, Storck S, Schmitt U, Zampar S, et al.
Cell Mol Life Sci
. 2022 Mar;
79(3):168.
PMID: 35235058
β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is the major described β-secretase to generate Aβ peptides in Alzheimer's disease (AD). However, all therapeutic attempts to block BACE1 activity and...
7.
Holder B, Tolan S, Heinrich K, Miller K, Hudson N, Nehra G, et al.
Fluids Barriers CNS
. 2022 Mar;
19(1):19.
PMID: 35232464
Background: Scientific conferences are vital communication events for scientists in academia, industry, and government agencies. In the brain barriers research field, several international conferences exist that allow researchers to present...
8.
Storck S, Kurtyka M, Pietrzik C
Fluids Barriers CNS
. 2021 Jun;
18(1):27.
PMID: 34147102
The entry of blood-borne molecules into the brain is restricted by the blood-brain barrier (BBB). Various physical, transport and immune properties tightly regulate molecule movement between the blood and the...
9.
Storck S, Hartz A, Pietrzik C
Handb Exp Pharmacol
. 2021 Feb;
273:247-266.
PMID: 33580390
The accumulation of neurotoxic amyloid-beta (Aβ) in the brain is one of the characteristic hallmarks of Alzheimer's disease (AD). Aβ-peptide brain homeostasis is governed by its production and various clearance...
10.
Gindorf M, Storck S, Ohler A, Scharfenberg F, Becker-Pauly C, Pietrzik C
J Cereb Blood Flow Metab
. 2020 Feb;
41(1):31-44.
PMID: 32065075
The metalloprotease meprin β (Mep1b) is capable of cleaving cell-adhesion molecules in different tissues (e.g. skin, kidney and intestine) and is dysregulated in several diseases associated with barrier breakdown (Alzheimer´s...