Steffen E Storck
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Explore the profile of Steffen E Storck including associated specialties, affiliations and a list of published articles.
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20
Citations
675
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Recent Articles
11.
Marques A, Di Spiezio A, Thiessen N, Schmidt L, Grotzinger J, Lullmann-Rauch R, et al.
Autophagy
. 2019 Jul;
16(5):811-825.
PMID: 31282275
CTSD (cathepsin D) is one of the major lysosomal proteases indispensable for the maintenance of cellular proteostasis by turning over substrates of endocytosis, phagocytosis and autophagy. Consequently, CTSD deficiency leads...
12.
Van Gool B, Storck S, Reekmans S, Lechat B, Gordts P, Pradier L, et al.
Mol Neurobiol
. 2019 Apr;
56(10):7234-7245.
PMID: 31004319
The low-density lipoprotein receptor-related protein-1 (LRP1) has a dual role in the metabolism of the amyloid precursor protein (APP). In cellular models, LRP1 enhances amyloid-β (Aβ) generation via APP internalization...
13.
Walter S, Jumpertz T, Huttenrauch M, Ogorek I, Gerber H, Storck S, et al.
Acta Neuropathol
. 2018 Nov;
137(2):239-257.
PMID: 30426203
Brain accumulation and aggregation of amyloid-β (Aβ) peptides is a critical step in the pathogenesis of Alzheimer's disease (AD). Full-length Aβ peptides (mainly Aβ1-40 and Aβ1-42) are produced through sequential...
14.
Storck S, Hartz A, Bernard J, Wolf A, Kachlmeier A, Mahringer A, et al.
Brain Behav Immun
. 2018 Jul;
73:21-33.
PMID: 30041013
The accumulation of neurotoxic amyloid-beta (Aβ) in the brain is a characteristic hallmark of Alzheimer's disease (AD). The blood-brain barrier (BBB) provides a large surface area and has been shown...
15.
Di Spiezio A, Sandin E, Dore R, Muller-Fielitz H, Storck S, Bernau M, et al.
Mol Metab
. 2017 Dec;
8:13-22.
PMID: 29254602
Objective: Leptin is a key hormone in the control of appetite and body weight. Predominantly produced by white adipose tissue, it acts on the brain to inhibit homeostatic feeding and...
16.
Storck S, Pietrzik C
Pharm Res
. 2017 Sep;
34(12):2637-2651.
PMID: 28948494
The accumulation of the neurotoxin beta-amyloid (Aβ) is a major hallmark in Alzheimer's disease (AD). Aβ homeostasis in the brain is governed by its production and various clearance mechanisms. Both...
17.
Herr U, Strecker P, Storck S, Thomas C, Rabiej V, Junker A, et al.
Front Mol Neurosci
. 2017 May;
10:118.
PMID: 28496400
The low-density lipoprotein receptor-related protein 1, LRP1, interacts with APP and affects its processing. This is assumed to be mostly caused by the impact of LRP1 on APP endocytosis. More...
18.
Storck S, Meister S, Nahrath J, Meissner J, Schubert N, Di Spiezio A, et al.
J Clin Invest
. 2015 Dec;
126(1):123-36.
PMID: 26619118
According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor-related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to neurotoxic amyloid-β (Aβ) brain accumulation and drives Alzheimer's...
19.
Rabiej V, Pflanzner T, Wagner T, Goetze K, Storck S, Eble J, et al.
Exp Cell Res
. 2015 Nov;
340(1):102-15.
PMID: 26610862
The low density lipoprotein receptor-related protein 1 (LRP1) has been shown to interact with β1-integrin and regulate its surface expression. LRP1 knock-out cells exhibit altered cytoskeleton organization and decreased cell...
20.
Meister S, Storck S, Hameister E, Behl C, Weggen S, Clement A, et al.
J Cereb Blood Flow Metab
. 2015 Apr;
35(7):1112-21.
PMID: 25853911
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive paralysis due to the loss of primary and secondary motor neurons. Mutations in the Cu/Zn-superoxide dismutase (SOD1) gene...