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Stefan Svensson

Explore the profile of Stefan Svensson including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 18
Citations 315
Followers 0
Related Specialties
Biochemistry
Pharmacology
Molecular Biology
Top 10 Co-Authors
Jonas Uppenberg
Udo Oppermann
Bjorn Elleby
Lars Abrahmsen
Lena Jendeberg
Tjeerd Barf
Karin Stefansson
Thomas Lundback
Mona Sydow-Backman
Markus Thor
Published In
J Biol Chem
Bioorg Med Chem Lett
Biochim Biophys Acta
Eur J Pharmacol
Sci Rep
Affiliations
Soon will be listed here.
Recent Articles
1.
Long-Term Study of Hepatitis Delta Virus Infection at Secondary Care Centers: The Impact of Viremia on Liver-Related Outcomes
Kamal H, Westman G, Falconer K, Duberg A, Weiland O, Haverinen S, et al.
Hepatology . 2020 Mar; 72(4):1177-1190. PMID: 32145073
Background And Aims: Hepatitis delta virus (HDV) infection is associated with fast progression to liver cirrhosis and liver complications. Previous studies have, however, been mainly from tertiary care centers, with...
2.
Prediction of designer drugs: Synthesis and spectroscopic analysis of synthetic cathinone analogs that may appear on the Swedish drug market
Carlsson A, Sandgren V, Svensson S, Konradsson P, Dunne S, Josefsson M, et al.
Drug Test Anal . 2018 Feb; PMID: 29426062
The use of hyphenated analytical techniques in forensic drug screening enables simultaneous identification of a wide range of different compounds. However, the appearance of drug seizures containing new substances, mainly...
3.
Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability
Ottosson N, Wu X, Nolting A, Karlsson U, Lund P, Ruda K, et al.
Sci Rep . 2015 Aug; 5:13278. PMID: 26299574
Voltage-gated ion channels generate cellular excitability, cause diseases when mutated, and act as drug targets in hyperexcitability diseases, such as epilepsy, cardiac arrhythmia and pain. Unfortunately, many patients do not...
4.
N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors
Barf T, Lehmann F, Hammer K, Haile S, Axen E, Medina C, et al.
Bioorg Med Chem Lett . 2009 Feb; 19(6):1745-8. PMID: 19217286
Small molecule inhibitors of adipocyte fatty-acid binding protein (A-FABP) have gained renewed interest following the recent publication of pharmacologically beneficial effects of such inhibitors. Despite the potential utility of selective...
5.
The selectivity of tyrosine 280 of human 11beta-hydroxysteroid dehydrogenase type 1 in inhibitor binding
Kim K, Wang Z, Busby J, Tsuruda T, Chen M, Hale C, et al.
FEBS Lett . 2007 Feb; 581(5):995-9. PMID: 17306259
11beta-Hydroxysteroid dehydrogenase type 1 is a homodimer where the carboxyl terminus of one subunit covers the active site of the dimer partner. Based on the crystal structure with CHAPS, the...
6.
The role of tyrosine 177 in human 11beta-hydroxysteroid dehydrogenase type 1 in substrate and inhibitor binding: an unlikely hydrogen bond donor for the substrate
Kim K, Wang Z, Busby J, Tsuruda T, Chen M, Hale C, et al.
Biochim Biophys Acta . 2006 Apr; 1764(4):824-30. PMID: 16580270
The catalytic motif (YSASK) at the active site of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is conserved across different species. The crystal structures of the human, guinea pig and mouse enzymes...
7.
Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons
Hult M, Shafqat N, Elleby B, Mitschke D, Svensson S, Forsgren M, et al.
Mol Cell Endocrinol . 2006 Jan; 248(1-2):26-33. PMID: 16431016
The NADPH-dependent enzyme type 1 11beta-hydroxysteroid dehydrogenase (11beta-HSD1) activates in a tissue-specific manner circulating pro-glucocorticoid hormones (cortisone in humans) to the 11beta-OH ligand (cortisol in humans), which is able to...
8.
The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions
Ogg D, Elleby B, Norstrom C, Stefansson K, Abrahmsen L, Oppermann U, et al.
J Biol Chem . 2004 Nov; 280(5):3789-94. PMID: 15542590
The metabolic reduction of 11-keto groups in glucocorticoid steroids such as cortisone leads to the nuclear receptor ligand cortisol. This conversion is an example of pre-receptor regulation and constitutes a...
9.
Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target
Lehmann F, Haile S, Axen E, Medina C, Uppenberg J, Svensson S, et al.
Bioorg Med Chem Lett . 2004 Sep; 14(17):4445-8. PMID: 15357969
Low micromolar human A-FABP inhibitors were found by utilizing a fluorescence polarization assay, X-ray crystallography and modeling. The carbazole- and indole-based inhibitors displayed approximately 10-fold preferences over human H-FABP and...
10.
Crystal structure and biological implications of a bacterial albumin binding module in complex with human serum albumin
Lejon S, Frick I, Bjorck L, Wikstrom M, Svensson S
J Biol Chem . 2004 Jul; 279(41):42924-8. PMID: 15269208
Many bactericide species express surface proteins that interact with human serum albumin (HSA). Protein PAB from the anaerobic bacterium Finegoldia magna (formerly Peptostreptococcus magnus) represents one of these proteins. Protein...