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» Authors » Stanley W Marynowski

Stanley W Marynowski

Explore the profile of Stanley W Marynowski including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 316
Followers 0
Related Specialties
Oncology
Biochemistry
Nutritional Sciences
Top 10 Co-Authors
Shivendra V Singh
Dong Xiao
Julie A Arlotti
Yan Zeng
Eun-Ryeong Hahm
Dhimant Desai
Anna Herman-Antosiewicz
Anna A Powolny
Karen L Lew
Ajay Bommareddy
Published In
Cancer Res
Biochemistry
Nutr Cancer
Clin Cancer Res
Carcinogenesis
Affiliations
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Recent Articles
1.
Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells
Singh S, Warin R, Xiao D, Powolny A, Stan S, Arlotti J, et al.
Cancer Res . 2009 Feb; 69(5):2117-25. PMID: 19223537
The present study shows that oral gavage of 6 mumol d,l-sulforaphane (SFN), a synthetic analogue of cruciferous vegetable-derived L isomer, thrice per week beginning at 6 weeks of age, significantly...
2.
Garlic constituent diallyl trisulfide prevents development of poorly differentiated prostate cancer and pulmonary metastasis multiplicity in TRAMP mice
Singh S, Powolny A, Stan S, Xiao D, Arlotti J, Warin R, et al.
Cancer Res . 2008 Nov; 68(22):9503-11. PMID: 19010926
Identification of agents that are nontoxic but can delay onset and/or progression of prostate cancer, which is the second leading cause of cancer-related deaths among men in the United States,...
3.
Honokiol, a constituent of oriental medicinal herb magnolia officinalis, inhibits growth of PC-3 xenografts in vivo in association with apoptosis induction
Hahm E, Arlotti J, Marynowski S, Singh S
Clin Cancer Res . 2008 Feb; 14(4):1248-57. PMID: 18281560
Purpose: This study was undertaken to determine the efficacy of honokiol, a constituent of oriental medicinal herb Magnolia officinalis, against human prostate cancer cells in culture and in vivo. Experimental...
4.
Diallyl trisulfide inhibits angiogenic features of human umbilical vein endothelial cells by causing Akt inactivation and down-regulation of VEGF and VEGF-R2
Xiao D, Li M, Herman-Antosiewicz A, Antosiewicz J, Xiao H, Lew K, et al.
Nutr Cancer . 2006 Sep; 55(1):94-107. PMID: 16965246
We have shown recently that diallyl trisulfide (DATS), a cancer-chemopreventive constituent of garlic, inactivates Akt to trigger mitochondrial translocation of proapoptotic protein BAD in human prostate cancer cells. Because Akt...
5.
Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential
Xiao D, Lew K, Zeng Y, Xiao H, Marynowski S, Dhir R, et al.
Carcinogenesis . 2006 Jun; 27(11):2223-34. PMID: 16774948
The present study was undertaken to gain insights into the molecular mechanism of apoptosis induction by phenethyl isothiocyanate (PEITC), which is a cancer chemopreventive constituent of cruciferous vegetables, using PC-3...
6.
c-Jun NH(2)-terminal kinase signaling axis regulates diallyl trisulfide-induced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells
Antosiewicz J, Herman-Antosiewicz A, Marynowski S, Singh S
Cancer Res . 2006 May; 66(10):5379-86. PMID: 16707465
We have shown previously that generation of reactive oxygen species (ROS) is a critical event in G(2)-M phase cell cycle arrest caused by diallyl trisulfide (DATS), which is a highly...
7.
Structural basis for catalytic differences between alpha class human glutathione transferases hGSTA1-1 and hGSTA2-2 for glutathione conjugation of environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide
Singh S, Varma V, Zimniak P, Srivastava S, Marynowski S, Desai D, et al.
Biochemistry . 2004 Jul; 43(30):9708-15. PMID: 15274625
The ultimate diol epoxide carcinogens derived from polycyclic aromatic hydrocarbons, such as benzo[a]pyrene (BP), are metabolized primarily by glutathione (GSH) conjugation reaction catalyzed by GSH transferases (GSTs). In human liver...