William B Isaacs
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Explore the profile of William B Isaacs including associated specialties, affiliations and a list of published articles.
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321
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17920
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Recent Articles
1.
Arafa A, Yadav S, Marshall C, Mauer E, Huang M, Yilma B, et al.
Clin Cancer Res
. 2025 Feb;
PMID: 40019487
Background: Germline alterations in homologous recombination repair (gHRR) genes impact the pathogenesis, treatment options, and survival of cancer patients. However, distinct gHRR gene alterations may differentially impact treatment response and...
2.
Feng B, Boyle J, Wei J, Carroll C, Snyder N, Shi Z, et al.
Prostate Cancer Prostatic Dis
. 2024 Aug;
PMID: 39154125
Background: Recent advances in the detection and treatment of prostate cancer (PCa) have reduced morbidity and mortality from this common cancer. Despite these improvements, PCa remains the second leading cause...
3.
Grindedal E, Zucknick M, Stormorken A, Ronne E, Tandstad N, Isaacs W, et al.
Prostate
. 2024 Apr;
84(10):945-953.
PMID: 38629217
Background: Pathogenic germline variants in the mismatch repair (MMR) genes are associated with an increased risk of prostate cancer (PCa). Since 2010 we have recommended MMR carriers annual PSA testing...
4.
Dairo O, DePaula Oliveira L, Schaffer E, Vidotto T, Mendes A, Lu J, et al.
Cancer Res Commun
. 2023 Dec;
4(1):152-163.
PMID: 38112617
Significance: Here, we leverage multiple independent primary and metastatic prostate cancer cohorts to demonstrate that FASN gene body methylation is highly inversely correlated with FASN gene and protein expression. This...
5.
Wang A, Shen J, Rodriguez A, Saunders E, Chen F, Janivara R, et al.
Nat Genet
. 2023 Nov;
55(12):2065-2074.
PMID: 37945903
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry...
6.
Patel R, Sayar E, Coleman I, Roudier M, Hanratty B, Low J, et al.
J Pathol
. 2023 Oct;
262(1):105-120.
PMID: 37850574
HOXB13 is a key lineage homeobox transcription factor that plays a critical role in the differentiation of the prostate gland. Several studies have suggested that HOXB13 alterations may be involved...
7.
Kanayama M, Chen Y, Rabizadeh D, Vera L, Lu C, Nielsen S, et al.
Eur Urol Oncol
. 2023 Oct;
7(4):751-759.
PMID: 37806842
Background: Recent reports have uncovered a HOXB13 variant (X285K) predisposing to prostate cancer in men of West African ancestry. The clinical relevance and protein function associated with this inherited variant...
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9.
Darst B, Shen J, Madduri R, Rodriguez A, Xiao Y, Sheng X, et al.
Am J Hum Genet
. 2023 Jun;
110(7):1200-1206.
PMID: 37311464
Genome-wide polygenic risk scores (GW-PRSs) have been reported to have better predictive ability than PRSs based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several...
10.
Darst B, Shen J, Madduri R, Rodriguez A, Xiao Y, Sheng X, et al.
medRxiv
. 2023 Jun;
PMID: 37292833
Genome-wide polygenic risk scores (GW-PRS) have been reported to have better predictive ability than PRS based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several...