The TERT Promoter is Polycomb-Repressed in Neuroblastoma Cells with Long Telomeres

Overview

Journal Cancer Res Commun

Specialty Oncology

Date 2024 Jun 5

PMID 38837897

Authors

Mindy K Graham

Beisi Xu

Christine Davis

Alan K Meeker

Christopher M Heaphy

Srinivasan Yegnasubramanian

Michael A Dyer

Maged Zeineldin

Affiliations

Soon will be listed here.

Abstract

Significance: The epigenetic landscape of the TERT locus is unique in neuroblastoma. The DNA at the TERT locus, unlike other cancer cells and similar to normal cells, are hypomethylated in telomerase-positive neuroblastoma cells. The TERT locus is repressed by polycomb repressive complex-2 complex in neuroblastoma cells that have long telomeres and do not express TERT. Long telomeres in neuroblastoma cells are also associated with repressive chromatin states at the chromosomal termini, suggesting TPE.

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