Sree Deepthi Muthukrishnan
Overview
Explore the profile of Sree Deepthi Muthukrishnan including associated specialties, affiliations and a list of published articles.
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18
Citations
312
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Recent Articles
1.
Bastola S, Pavlyukov M, Sharma N, Ghochani Y, Nakano M, Muthukrishnan S, et al.
Nat Commun
. 2025 Jan;
16(1):471.
PMID: 39773984
Extensive neovascularization is a hallmark of glioblastoma (GBM). In addition to supplying oxygen and nutrients, vascular endothelial cells provide trophic support to GBM cells via paracrine signaling. Here we report...
2.
Pathikonda S, Amirmahani F, Mathew D, Muthukrishnan S
Cancer Lett
. 2024 Sep;
604:217269.
PMID: 39326554
Glioblastoma (GBM) is a fatal adult brain tumor with an extremely poor prognosis. GBM poses significant challenges for targeted therapies due to its intra- and inter-tumoral heterogeneity, a highly immunosuppressive...
3.
Patel K, Tessema K, Kawaguchi R, Dudley L, Alvarado A, Muthukrishnan S, et al.
Neurooncol Adv
. 2024 Apr;
6(1):vdae005.
PMID: 38616896
Background: Non-enhancing (NE) infiltrating tumor cells beyond the contrast-enhancing (CE) bulk of tumor are potential propagators of recurrence after gross total resection of high-grade glioma. Methods: We leveraged single-nucleus RNA...
4.
Muthukrishnan S, Qi H, Wang D, Elahi L, Pham A, Alvarado A, et al.
Mol Cancer Res
. 2024 Mar;
22(7):656-667.
PMID: 38441553
A key feature distinguishing high-grade glioma (HG) from low-grade glioma (LG) is the extensive neovascularization and endothelial hyperproliferation. Prior work has shown that tumor-associated vasculature from HG is molecularly and...
5.
Ludwig K, Le Belle J, Muthukrishnan S, Sperry J, Condro M, Vlashi E, et al.
Antioxid Redox Signal
. 2023 Jul;
39(13-15):890-903.
PMID: 37470216
The goal of this study was to determine whether nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX)-produced reactive oxygen species (ROS) enhance brain tumor growth of glioblastoma (GBM) under hypoxic conditions...
6.
Muthukrishnan S, Qi H, Wang D, Elahi L, Pham A, Alvarado A, et al.
bioRxiv
. 2023 Jul;
PMID: 37461434
Background: A key feature distinguishing high-grade glioma (HGG) from low-grade glioma (LGG) is the extensive neovascularization and endothelial hyperproliferation. Prior work has shown that tumor endothelial cells (TEC) from HGG...
7.
Muthukrishnan S, Kawaguchi R, Nair P, Prasad R, Qin Y, Johnson M, et al.
Nat Commun
. 2022 Oct;
13(1):6202.
PMID: 36261421
Glioma stem cells (GSC) exhibit plasticity in response to environmental and therapeutic stress leading to tumor recurrence, but the underlying mechanisms remain largely unknown. Here, we employ single-cell and whole...
8.
Ghochani Y, Muthukrishnan S, Sohrabi A, Kawaguchi R, Condro M, Bastola S, et al.
Cell Rep
. 2022 Oct;
41(3):111511.
PMID: 36261010
Glioblastoma (GBM) is characterized by extensive microvascular hyperproliferation. In addition to supplying blood to the tumor, GBM vessels also provide trophic support to glioma cells and serve as conduits for...
9.
Alvarado A, Tessema K, Muthukrishnan S, Sober M, Kawaguchi R, Laks D, et al.
Cancer Res Commun
. 2022 Oct;
2(9):1049-1060.
PMID: 36213002
Analysis of tumor gene expression is an important approach for the classification and identification of therapeutic vulnerabilities. However, targeting glioblastoma (GBM) based on molecular subtyping has not yet translated into...
10.
Kaneko N, Satta S, Komuro Y, Muthukrishnan S, Kakarla V, Guo L, et al.
Stroke
. 2020 Nov;
52(1):260-270.
PMID: 33161843
Background And Purpose: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated with an increased rate of cerebrovascular events including ischemic stroke and intracerebral hemorrhage. The mechanisms underlying cerebral endothelial...