Harley I Kornblum
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Explore the profile of Harley I Kornblum including associated specialties, affiliations and a list of published articles.
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119
Citations
5870
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Recent Articles
1.
He L, Azizad D, Bhat K, Ioannidis A, Hoffmann C, Arambula E, et al.
Proc Natl Acad Sci U S A
. 2025 Feb;
122(9):e2415557122.
PMID: 40009641
Glioblastoma (GBM) is the deadliest brain cancer in adults, and all patients succumb to the tumor. While surgery followed by chemoradiotherapy delays disease progression, these treatments do not lead to...
2.
Masterman-Smith M, Graham N, Panosyan E, Mottahedeh J, Samuels E, Nunez A, et al.
Cancer Res Treat
. 2025 Jan;
PMID: 39788641
Purpose: In glioblastoma, the therapeutically intractable and resistant phenotypes can be derived from glioma stem cells, which often have different underlying mechanisms from non-stem glioma cells. Aberrant signaling across the...
3.
Bastola S, Pavlyukov M, Sharma N, Ghochani Y, Nakano M, Muthukrishnan S, et al.
Nat Commun
. 2025 Jan;
16(1):471.
PMID: 39773984
Extensive neovascularization is a hallmark of glioblastoma (GBM). In addition to supplying oxygen and nutrients, vascular endothelial cells provide trophic support to GBM cells via paracrine signaling. Here we report...
4.
Patel K, Dudley L, Kornblum H
Neuron
. 2024 Dec;
112(24):3987-3988.
PMID: 39701039
The identification of stem cells in glioblastomas has been controversial. In this issue of Neuron, Xie et al. establish gene signatures for cellular states and a quiescent cancer stem cell...
5.
Elahi L, Condro M, Kawaguchi R, Qin Y, Alvarado A, Gruender B, et al.
NPJ Metab Health Dis
. 2024 Aug;
2(1):20.
PMID: 39149696
Histone deacetylases (HDACs) have a wide range of targets and can rewire both the chromatin and lipidome of cancer cells. In this study, we show that valproic acid (VPA), a...
6.
He L, Ioannidis A, Hoffman C, Arambula E, Joshi P, Whitelegge J, et al.
Cancer Res Commun
. 2024 Jun;
4(6):1566-1580.
PMID: 38837899
Significance: Combination therapies that activate the mevalonate pathway in GBM cells after sublethal treatment enhance self-renewal and migratory capacity through Rac-1 activation, which creates a metabolic vulnerability that can be...
7.
He L, Azizad D, Bhat K, Ioannidis A, Hoffmann C, Arambula E, et al.
bioRxiv
. 2024 May;
PMID: 38798647
Glioblastoma is the deadliest brain cancer in adults and almost all patients succumb to the tumor. While surgery followed by chemo-radiotherapy significantly delays disease progression, these treatments do not lead...
8.
Patel K, Tessema K, Kawaguchi R, Dudley L, Alvarado A, Muthukrishnan S, et al.
Neurooncol Adv
. 2024 Apr;
6(1):vdae005.
PMID: 38616896
Background: Non-enhancing (NE) infiltrating tumor cells beyond the contrast-enhancing (CE) bulk of tumor are potential propagators of recurrence after gross total resection of high-grade glioma. Methods: We leveraged single-nucleus RNA...
9.
Pianka S, Li T, Prins T, Eldred B, Kevan B, Liang H, et al.
Cancer Res Commun
. 2024 Mar;
4(3):876-894.
PMID: 38445960
Significance: We show that IDH1mut-generated D-2-HG can reduce glioma growth via inhibition of the m6A demethylase, FTO. FTO inhibition represents a potential therapeutic target for IDH1wt gliomas and possibly in...
10.
Muthukrishnan S, Qi H, Wang D, Elahi L, Pham A, Alvarado A, et al.
Mol Cancer Res
. 2024 Mar;
22(7):656-667.
PMID: 38441553
A key feature distinguishing high-grade glioma (HG) from low-grade glioma (LG) is the extensive neovascularization and endothelial hyperproliferation. Prior work has shown that tumor-associated vasculature from HG is molecularly and...