Sonia Manzanaro
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Explore the profile of Sonia Manzanaro including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
51
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Recent Articles
1.
Cousido-Siah A, Ruiz F, Mitschler A, Porte S, de Lera A, Martin M, et al.
Acta Crystallogr D Biol Crystallogr
. 2014 Mar;
70(Pt 3):889-903.
PMID: 24598757
Aldo-keto reductases (AKRs) are mostly monomeric enzymes which fold into a highly conserved (α/β)8 barrel, while their substrate specificity and inhibitor selectivity are determined by interaction with residues located in...
2.
Vermeulen W, Filliers W, Garcia C, Manzanaro S, Montalvo D, Polanco C, et al.
Magn Reson Chem
. 2008 Sep;
46(12):1198-202.
PMID: 18821578
This article presents the structure elucidation of four new compounds, formed during the hemisynthetic preparation of trabectedin, an anti-tumor natural product from Ecteinascidia turbinata. We report herein on the use...
3.
Manzanaro S, Salva J, de la Fuente J
J Nat Prod
. 2006 Oct;
69(10):1485-7.
PMID: 17067167
Four different types of marine natural compounds isolated from tunicates were found to inhibit human aldose reductase. They all are characterized by a heterocyclic system, and at least two phenolic...
4.
Vicent M, Manzanaro S, de la Fuente J, Duncan R
J Drug Target
. 2004 Dec;
12(8):503-15.
PMID: 15621676
1,5-diazaanthraquinones (DAQs) are promising anticancer drugs, however, their clinical potential is limited due to poor solubility. Conjugation of anticancer agents to hydrophilic water-soluble polymers can overcome this problem and has...
5.
Manzanaro S, Vicent M, Martin M, Salvador-Tormo N, Perez J, Blanco M, et al.
Bioorg Med Chem
. 2004 Nov;
12(24):6505-15.
PMID: 15556767
A series of 1,5-diazaanthraquinone derivatives was synthesized and their in vitro cytotoxic activities were evaluated against several human cancer cell lines. The 1,5-diazaanthraquinone chromophore has been synthesized either on the...
6.
Avendano C, Perez J, Blanco M, de la Fuente J, Manzanaro S, Vicent M, et al.
Bioorg Med Chem Lett
. 2004 Jul;
14(15):3929-32.
PMID: 15225700
1,5-Diazaanthraquinone derivatives were synthesized employing single and double hetero Diels-Alder strategies. Their in vitro antitumour activity was assayed using three cell lines. Some of these compounds, specially those bearing methyl...
7.
de la Fuente J, Manzanaro S, Martin M, de Quesada T, Reymundo I, Luengo S, et al.
J Med Chem
. 2003 Nov;
46(24):5208-21.
PMID: 14613323
Aldose reductase (ALR2) has been implicated in the etiology of diabetic complications, including blindness. Because of the limited number of currently available drugs for the prevention of these long-term complications,...
8.
de la Fuente J, Manzanaro S
Nat Prod Rep
. 2003 May;
20(2):243-51.
PMID: 12735699
This review covers aldose reductase inhibitors (ARIs) isolated from natural sources. Compounds in the review are grouped according to the source from which they have been isolated: terrestrial, marine, or...