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Phenolic Marine Natural Products As Aldose Reductase Inhibitors

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Journal J Nat Prod
Date 2006 Oct 28
PMID 17067167
Citations 16
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Abstract

Four different types of marine natural compounds isolated from tunicates were found to inhibit human aldose reductase. They all are characterized by a heterocyclic system, and at least two phenolic groups are present in the structure. Two of the compounds tested showed an inhibitory potency 5/6-fold higher than that of the known AR inhibitor sorbinil. One notable structural feature of these active compounds is the lack of either the carboxylic acid or the spiro-hydantoin commonly present in the principal classes of currently used inhibitors.

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