Sofie Peirs
Overview
Explore the profile of Sofie Peirs including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
14
Citations
471
Followers
0
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Recent Articles
1.
Di Grande A, Peirs S, Donovan P, Van Trimpont M, Morscio J, Lintermans B, et al.
Blood Adv
. 2021 Apr;
5(7):1963-1976.
PMID: 33830207
B-cell lymphoma 2 (BCL-2) has recently emerged as a therapeutic target for early T-cell progenitor acute lymphoblastic leukemia (ETP-ALL), a high-risk subtype of human T-cell ALL. The major clinical challenge...
2.
Matthijssens F, Sharma N, Nysus M, Nickl C, Kang H, Perez D, et al.
J Clin Invest
. 2021 Feb;
131(6).
PMID: 33555272
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared with that of B cell ALL. Here, we show that Runt-related transcription factor 2 (RUNX2)...
3.
Pouliot G, Degar J, Hinze L, Kochupurakkal B, Vo C, Burns M, et al.
PLoS One
. 2019 Nov;
14(11):e0221288.
PMID: 31721781
BRCA2 (also known as FANCD1) is a core component of the Fanconi pathway and suppresses transformation of immature T-cells in mice. However, the contribution of Fanconi-BRCA pathway deficiency to human...
4.
Aries I, Bodaar K, Karim S, Chonghaile T, Hinze L, Burns M, et al.
J Exp Med
. 2018 Nov;
215(12):3094-3114.
PMID: 30404791
The tendency of mitochondria to undergo or resist BCL2-controlled apoptosis (so-called mitochondrial priming) is a powerful predictor of response to cytotoxic chemotherapy. Fully exploiting this finding will require unraveling the...
5.
Jin Q, Martinez C, Arcipowski K, Zhu Y, Gutierrez-Diaz B, Wang K, et al.
Clin Cancer Res
. 2018 Sep;
25(1):222-239.
PMID: 30224337
Purpose: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease, affecting children and adults. Chemotherapy treatments show high response rates but have debilitating effects and carry risk of relapse. Previous...
6.
De Smedt R, Peirs S, Morscio J, Matthijssens F, Roels J, Reunes L, et al.
Haematologica
. 2018 Aug;
104(1):e17-e20.
PMID: 30076176
No abstract available.
7.
Milani G, Matthijssens F, Van Loocke W, Durinck K, Roels J, Peirs S, et al.
Br J Haematol
. 2018 Jun;
185(1):169-174.
PMID: 29938777
No abstract available.
8.
Nguyen H, Su Y, Zhang J, Antanasijevic A, Caffrey M, Schalk A, et al.
Cancer Res
. 2018 Jan;
78(6):1549-1560.
PMID: 29343523
Acute lymphoblastic leukemia (ALL) is the most common type of pediatric cancer, although about 4 of every 10 cases occur in adults. The enzyme drug l-asparaginase serves as a cornerstone...
9.
Goossens S, Peirs S, Van Loocke W, Wang J, Takawy M, Matthijssens F, et al.
Blood
. 2017 Jan;
129(8):981-990.
PMID: 28069602
Elevated expression of the Zinc finger E-box binding homeobox transcription factor-2 (ZEB2) is correlated with poor prognosis and patient outcome in a variety of human cancer subtypes. Using a conditional...
10.
Unnikrishnan A, Guan Y, Huang Y, Beck D, Thoms J, Peirs S, et al.
Nucleic Acids Res
. 2016 Sep;
44(22):10644-10661.
PMID: 27604872
Aberrant stem cell-like gene regulatory networks are a feature of leukaemogenesis. The ETS-related gene (ERG), an important regulator of normal haematopoiesis, is also highly expressed in T-ALL and acute myeloid...