Sinead M Miggin
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Explore the profile of Sinead M Miggin including associated specialties, affiliations and a list of published articles.
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22
Citations
468
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Recent Articles
11.
OHanlon K, Cairns T, Stack D, Schrettl M, Bignell E, Kavanagh K, et al.
Infect Immun
. 2011 Jul;
79(10):3978-92.
PMID: 21746855
Nonribosomal peptide synthesis (NRPS) is a documented virulence factor for the opportunistic pathogen Aspergillus fumigatus and other fungi. Secreted or intracellularly located NRP products include the toxic molecule gliotoxin and...
12.
Siednienko J, Gajanayake T, Fitzgerald K, Moynagh P, Miggin S
J Immunol
. 2011 Jan;
186(4):2514-22.
PMID: 21248248
Toll-like receptors are a group of pattern-recognition receptors that play a crucial role in "danger" recognition and induction of the innate immune response against bacterial and viral infections. TLR3 has...
13.
Siednienko J, Halle A, Nagpal K, Golenbock D, Miggin S
Eur J Immunol
. 2010 Oct;
40(11):3150-60.
PMID: 20957750
There is limited insight into the mechanisms involved in the counterregulation of TLR. Given the important role of TLR3/TIR domain-containing adaptor-inducing IFN-β (TRIF)-dependent signalling in innate immunity, novel insights into...
14.
Siednienko J, Miggin S
Methods Mol Biol
. 2009 Apr;
517:3-14.
PMID: 19378036
Toll-like receptors (TLRs) are key regulators of the innate and adaptive immune response to bacterial, viral, and fungal pathogens. To date, 10 human TLRs and 13 mouse TLRs have been...
15.
Miggin S, Palsson-McDermott E, Dunne A, Jefferies C, Pinteaux E, Banahan K, et al.
Proc Natl Acad Sci U S A
. 2007 Mar;
104(9):3372-7.
PMID: 17360653
Toll-like receptors (TLRs)-2 and -4 are important proteins in innate immunity, recognizing microbial products and eliciting host defense responses. Both use the adapter proteins MyD88 and MyD88 adapter-like (Mal) to...
16.
Miggin S, ONeill L
J Leukoc Biol
. 2006 May;
80(2):220-6.
PMID: 16698941
Toll-like receptor (TLR) activation is dictated by a number of factors including the ligand itself and the localization of the receptor, in terms of expression profile and subcellular localization and...
17.
Wietek C, Miggin S, Jefferies C, ONeill L
J Biol Chem
. 2003 Oct;
278(51):50923-31.
PMID: 14557267
Interferon regulatory factor (IRF) 3 is a transcription factor that binds the interferon-sensitive response element (ISRE) and is activated by Toll-like receptor 3 (TLR3) and TLR4. We have found that...
18.
Miggin S, Lawler O, Kinsella B
J Biol Chem
. 2002 Dec;
278(9):6947-58.
PMID: 12488443
We have previously established that isoprenylation of the prostacyclin receptor (IP) is required for its efficient G protein coupling and effector signaling (Hayes, J. S., Lawler, O. A., Walsh, M....
19.
Coyle A, Miggin S, Kinsella B
Eur J Biochem
. 2002 Aug;
269(16):4058-73.
PMID: 12180983
In humans, thromboxane (TX) A2 signals through two TXA2 receptor (TP) isoforms, TPalpha and TPbeta, that diverge within their carboxyl terminal cytoplasmic (C) tail regions and arise by differential splicing....
20.
Miggin S, Kinsella B
J Biol Chem
. 2002 May;
277(30):27053-64.
PMID: 12016224
We recently identified a novel mechanism explaining how the mouse (m) prostacyclin receptor (IP) couples to Galpha(s), Galpha(i), and Galpha(q) (Lawler, O. A., Miggin, S. M., and Kinsella, B. T....