Simone Sidoli
Overview
Explore the profile of Simone Sidoli including associated specialties, affiliations and a list of published articles.
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Articles
208
Citations
4167
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Recent Articles
1.
Jani V, Yoo E, Binek A, Guo A, Kim J, Aguilan J, et al.
J Am Heart Assoc
. 2025 Mar;
:e038945.
PMID: 40079330
Background: Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all HF but has few effective therapies. Recent human myocardial transcriptomics and metabolomics have identified major differences...
2.
Singh B, Fredriksson Sundbom M, Muthukrishnan U, Natarajan B, Stransky S, Gorgens A, et al.
J Extracell Vesicles
. 2025 Feb;
14(2):e70042.
PMID: 39976275
Histones are conserved nuclear proteins that function as part of the nucleosome in the regulation of chromatin structure and gene expression. Interestingly, extracellular histones populate biofluids from healthy individuals, and...
3.
Sun Y, Houde D, Iacob R, Baird J, Swift R, Holliday M, et al.
Anal Chem
. 2025 Feb;
97(8):4329-4340.
PMID: 39969248
Characterizing protein-ligand interactions is crucial to understanding cellular metabolism and guiding drug discovery and development. Herein, we explore complementing hydrogen/deuterium exchange mass spectrometry (HDX-MS) with a recently developed Fenton chemistry-based...
4.
Rao L, Liu X, Berger F, McKenney R, Arnold M, Stengel K, et al.
bioRxiv
. 2025 Jan;
PMID: 39868132
Cytoplasmic dynein is an essential microtubule motor protein that powers organelle transport and mitotic spindle assembly. Its activity depends on dynein-dynactin-cargo adaptor complexes, such as dynein-dynactin-BicD2 (DDB), which typically function...
5.
Kuwik J, Scott V, Chedid S, Stransky S, Hinkelman K, Kavoosi S, et al.
J Am Chem Soc
. 2025 Jan;
147(4):3341-3352.
PMID: 39808475
Lysine demethylases (KDMs) catalyze the oxidative removal of the methyl group from histones using earth-abundant iron and the metabolite 2-oxoglutarate (2OG). KDMs have emerged as master regulators of eukaryotic gene...
6.
Zheng Q, Weekley B, Vinson D, Zhao S, Bastle R, Thompson R, et al.
Nature
. 2025 Jan;
637(8047):974-982.
PMID: 39779849
Histone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression. We previously demonstrated that serotonylation and dopaminylation of...
7.
Akhlaq R, Ahmed T, Khan T, Yaseen Jeelani S, Joseph-Chowdhury J, Sidoli S, et al.
Epigenomics
. 2024 Dec;
17(2):79-87.
PMID: 39716806
Aim: The hypoxic tumor microenvironment (TME) in oral squamous cell carcinoma (OSCC) is primarily regulated by hypoxia-inducible factor-1 alpha (HIF-1α), impacting histone acetylation and methylation, which contribute to drug resistance....
8.
Fisher R, Park K, Lee K, Pinjusic K, Vanasse A, Ennis C, et al.
bioRxiv
. 2024 Dec;
PMID: 39713349
Statement Of Significance: We identify a novel role of the CoREST transcriptional repressor complex in regulating pre-mRNA splicing and find that the small molecule inhibitor, corin, promotes alternative splicing events...
9.
Smoking-Associated Carcinogen-Induced Inflammation Promotes Lung Carcinogenesis via IRAK4 Activation
Aggarwal R, Sidoli S, Wang J, Sahu S, Sanawar R, Gupta V, et al.
Clin Cancer Res
. 2024 Dec;
31(4):746-755.
PMID: 39704655
Purpose: Even though smoking is associated with lung cancer, the exact molecular pathways that link carcinogens with inflammation and oncogenic transformation are not well elucidated. Two major carcinogens in cigarette...
10.
Yheskel M, Castiglione M, Kelly R, Sidoli S, Secombe J
bioRxiv
. 2024 Dec;
PMID: 39677601
KDM5 family proteins are best known for their demethylation of the promoter proximal chromatin mark H3K4me3. KDM5-regulated transcription is critical in the brain, with variants in the X-linked paralog causing...