Jennifer T Aguilan
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Explore the profile of Jennifer T Aguilan including associated specialties, affiliations and a list of published articles.
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20
Citations
194
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Recent Articles
1.
Nakane K, Morisseau C, Dowker-Key P, Benitez G, Aguilan J, Nagai E, et al.
ACS Med Chem Lett
. 2024 Nov;
15(11):1891-1898.
PMID: 39563815
Soluble epoxide hydrolase (sEH) is a bifunctional enzyme involved in fatty acid metabolism and a promising drug target. We previously reported first-generation sEH proteolysis-targeting chimeras (PROTACs) with limited degradation potency...
2.
Tuleta I, Hanna A, Humeres C, Aguilan J, Sidoli S, Zhu F, et al.
Cardiovasc Res
. 2024 Oct;
120(16):2047-2063.
PMID: 39373248
Aims: Transforming growth factor (TGF)-β is up-regulated in the diabetic myocardium and may mediate fibroblast activation. We aimed at examining the role of TGF-β-induced fibroblast activation in the pathogenesis of...
3.
Graff R, Haimowitz A, Aguilan J, Levine A, Zhang J, Yuan W, et al.
bioRxiv
. 2024 Sep;
PMID: 39314490
Significance: We demonstrate that platelet PI3Kβ regulates metastasis, broadening the potential use of PI3Kβ-selective inhibitors as novel agents to treat metastasis.
4.
Nakane K, Morisseau C, Dowker-Key P, Benitez G, Aguilan J, Nagai E, et al.
bioRxiv
. 2024 Aug;
PMID: 39211216
Soluble epoxide hydrolase (sEH) is a bifunctional enzyme involved in fatty acid metabolism and promising drug target. We previously reported first-generation sEH proteolysis-targeting chimeras (PROTACs) with limited degradation potency and...
5.
Aguilan J, Lim J, Racine-Brzostek S, Fischer J, Silvescu C, Cornett S, et al.
Clin Proteomics
. 2024 Jul;
21(1):47.
PMID: 38961380
Amyloidosis is a disease characterized by local and systemic extracellular deposition of amyloid protein fibrils where its excessive accumulation in tissues and resistance to degradation can lead to organ failure....
6.
Humeres C, Shinde A, Tuleta I, Hernandez S, Hanna A, Huang S, et al.
Circ Res
. 2024 Jun;
135(3):453-469.
PMID: 38899461
Background: Cardiac fibroblast activation contributes to adverse remodeling, fibrosis, and dysfunction in the pressure-overloaded heart. Although early fibroblast TGF-β (transforming growth factor-β)/Smad (small mother against decapentaplegic)-3 activation protects the pressure-overloaded...
7.
Mahant A, Trejo F, Aguilan J, Sidoli S, Permar S, Herold B
iScience
. 2023 Sep;
26(9):107648.
PMID: 37670782
Antibody-dependent cellular cytotoxicity (ADCC) is associated with protection against neonatal herpes. We hypothesized that placental transfer of ADCC-mediating herpes simplex virus (HSV) immunoglobulin G (IgG) is influenced by antigenic target,...
8.
Chitu V, Biundo F, Oppong-Asare J, Gokhan S, Aguilan J, Dulski J, et al.
Glia
. 2023 Jul;
71(11):2664-2678.
PMID: 37519044
Mutations leading to colony-stimulating factor-1 receptor (CSF-1R) loss-of-function or haploinsufficiency cause CSF1R-related leukoencephalopathy (CRL), an adult-onset disease characterized by loss of myelin and neurodegeneration, for which there is no effective...
9.
Aguilan J, Pedrosa E, Dolstra H, Baykara R, Barnes J, Zhang J, et al.
bioRxiv
. 2023 Jul;
PMID: 37461463
Background: Jansen de Vries Syndrome (JdVS) is a rare neurodevelopmental disorder (NDD) caused by gain-of-function (GOF) truncating mutations in exons 5 or 6. PPM1D is a serine/threonine phosphatase that plays...
10.
Martinez-Lopez N, Mattar P, Toledo M, Bains H, Kalyani M, Aoun M, et al.
Nat Cell Biol
. 2023 Jun;
25(7):989-1003.
PMID: 37386153
Fasting triggers diverse physiological adaptations including increases in circulating fatty acids and mitochondrial respiration to facilitate organismal survival. The mechanisms driving mitochondrial adaptations and respiratory sufficiency during fasting remain incompletely...