Mariel Coradin
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Explore the profile of Mariel Coradin including associated specialties, affiliations and a list of published articles.
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20
Citations
443
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Recent Articles
1.
Pashos A, Meyer A, Bussey-Sutton C, OConnor E, Coradin M, Coulombe M, et al.
Nat Cell Biol
. 2025 Jan;
27(2):202-217.
PMID: 39779942
Plasticity is needed during development and homeostasis to generate diverse cell types from stem and progenitor cells. Following differentiation, plasticity must be restricted in specialized cells to maintain tissue integrity...
2.
Serdyukova K, Swearingen A, Coradin M, Nevo M, Tran H, Bajric E, et al.
Development
. 2023 Oct;
150(21).
PMID: 37846748
Histone modifications are associated with regulation of gene expression that controls a vast array of biological processes. Often, these associations are drawn by correlating the genomic location of a particular...
3.
Nucleome programming is required for the foundation of totipotency in mammalian germline development
Nagano M, Hu B, Yokobayashi S, Yamamura A, Umemura F, Coradin M, et al.
EMBO J
. 2022 Jun;
41(13):e110600.
PMID: 35703121
Germ cells are unique in engendering totipotency, yet the mechanisms underlying this capacity remain elusive. Here, we perform comprehensive and in-depth nucleome analysis of mouse germ-cell development in vitro, encompassing...
4.
von Gruning H, Coradin M, Mendoza M, Reader J, Sidoli S, Garcia B, et al.
Mol Cell Proteomics
. 2022 Jan;
21(3):100199.
PMID: 35051657
Histone posttranslational modifications (PTMs) frequently co-occur on the same chromatin domains or even in the same molecule. It is now established that these "histone codes" are the result of cross...
5.
Lund P, Lopes M, Sidoli S, Coradin M, Vitorino F, da Cunha J, et al.
Mol Omics
. 2021 Oct;
17(5):725-739.
PMID: 34636387
Paradoxically, oncogenes that drive cell cycle progression may also trigger pathways leading to senescence, thereby inhibiting the growth of tumorigenic cells. Knowledge of how these pathways operate, and how tumor...
6.
Lu C, Coradin M, Janssen K, Sidoli S, Garcia B
J Am Soc Mass Spectrom
. 2021 Apr;
32(6):1300-1311.
PMID: 33818074
The cell cycle is a highly regulated and evolutionary conserved process that results in the duplication of cell content and the equal distribution of the duplicated chromosomes into a pair...
7.
Farhangdoost N, Horth C, Hu B, Bareke E, Chen X, Li Y, et al.
Cell Rep
. 2021 Feb;
34(8):108769.
PMID: 33626351
Chromatin dysregulation has emerged as an important mechanism of oncogenesis. To develop targeted treatments, it is important to understand the transcriptomic consequences of mutations in chromatin modifier genes. Recently, mutations...
8.
Harutyunyan A, Chen H, Lu T, Horth C, Nikbakht H, Krug B, et al.
Cell Rep
. 2020 Nov;
33(7):108390.
PMID: 33207202
The discovery of H3K27M mutations in pediatric gliomas marked a new chapter in cancer epigenomics. Numerous studies have investigated the effect of this mutation on H3K27 trimethylation, but only recently...
9.
Accelerating the Field of Epigenetic Histone Modification Through Mass Spectrometry-Based Approaches
Lu C, Coradin M, Porter E, Garcia B
Mol Cell Proteomics
. 2020 Nov;
20:100006.
PMID: 33203747
Histone post-translational modifications (PTMs) are one of the main mechanisms of epigenetic regulation. Dysregulation of histone PTMs leads to many human diseases, such as cancer. Because of its high throughput,...
10.
Coradin M, Mendoza M, Sidoli S, Alpert A, Lu C, Garcia B
Methods
. 2020 Feb;
184:86-92.
PMID: 32070774
Middle-down proteomics has emerged as the method of choice to study combinatorial histone post translational modifications (PTMs). In the common bottom-up workflow, histones are digested into relatively short peptides (4-20...