Simon Junankar
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Explore the profile of Simon Junankar including associated specialties, affiliations and a list of published articles.
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19
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1801
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Recent Articles
11.
Oakes S, Gallego-Ortega D, Stanford P, Junankar S, Au W, Kikhtyak Z, et al.
PLoS Genet
. 2017 Nov;
13(11):e1007072.
PMID: 29117179
We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development. The mutation caused...
12.
Junankar S, Baker L, Roden D, Nair R, Elsworth B, Gallego-Ortega D, et al.
Nat Commun
. 2015 Mar;
6:6548.
PMID: 25813983
Basal-like breast cancer (BLBC) is a heterogeneous disease with poor prognosis; however, its cellular origins and aetiology are poorly understood. In this study, we show that inhibitor of differentiation 4...
13.
Junankar S, Shay G, Jurczyluk J, Ali N, Down J, Pocock N, et al.
Cancer Discov
. 2014 Oct;
5(1):35-42.
PMID: 25312016
Unlabelled: Recent clinical trials have shown that bisphosphonate drugs improve breast cancer patient survival independent of their antiresorptive effects on the skeleton. However, because bisphosphonates bind rapidly to bone mineral,...
14.
Ruffell B, Affara N, Cottone L, Junankar S, Johansson M, DeNardo D, et al.
Genes Dev
. 2013 Sep;
27(19):2086-98.
PMID: 24065739
Serine and cysteine cathepsin (Cts) proteases are an important class of intracellular and pericellular enzymes mediating multiple aspects of tumor development. Emblematic of these is CtsB, reported to play functionally...
15.
Nair R, Junankar S, OToole S, Shah J, Borowsky A, Bishop J, et al.
PLoS One
. 2010 Aug;
5(8):e11947.
PMID: 20689821
The accumulation of poorly differentiated cells is a hallmark of breast neoplasia and progression. Thus an understanding of the factors controlling mammary differentiation is critical to a proper understanding of...
16.
Sounni N, Dehne K, van Kempen L, Egeblad M, Affara N, Cuevas I, et al.
Dis Model Mech
. 2010 Mar;
3(5-6):317-32.
PMID: 20223936
Innate regulatory networks within organs maintain tissue homeostasis and facilitate rapid responses to damage. We identified a novel pathway regulating vessel stability in tissues that involves matrix metalloproteinase 14 (MMP14)...
17.
Andreu P, Johansson M, Affara N, Pucci F, Tan T, Junankar S, et al.
Cancer Cell
. 2010 Feb;
17(2):121-34.
PMID: 20138013
Chronically activated leukocytes recruited to premalignant tissues functionally contribute to cancer development; however, mechanisms underlying pro- versus anti-tumor programming of neoplastic tissues by immune cells remain obscure. Using the K14-HPV16...
18.
Johnen H, Lin S, Kuffner T, Brown D, Tsai V, Bauskin A, et al.
Nat Med
. 2007 Nov;
13(11):1333-40.
PMID: 17982462
Anorexia and weight loss are part of the wasting syndrome of late-stage cancer, are a major cause of morbidity and mortality in cancer, and are thought to be cytokine mediated....
19.
Bauskin A, Brown D, Junankar S, Rasiah K, Eggleton S, Hunter M, et al.
Cancer Res
. 2005 Mar;
65(6):2330-6.
PMID: 15781647
The extracellular matrix (ECM) is a reservoir of cellular binding proteins and growth factors that are critical for normal cell behavior, and aberrations in the ECM invariably accompany malignancies such...