Alexander Swarbrick
Overview
Explore the profile of Alexander Swarbrick including associated specialties, affiliations and a list of published articles.
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86
Citations
3324
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Recent Articles
1.
Parsons A, Colon E, Spasic M, Kurt B, Swarbrick A, Freedman R, et al.
Res Sq
. 2024 Nov;
PMID: 39483921
Aging is associated with increased breast cancer risk and outcomes are worse for the oldest and youngest patients, regardless of subtype. It is not known how cells in the breast...
2.
Wang T, Roach M, Harvey K, Morlanes J, Kiedik B, Al-Eryani G, et al.
Commun Biol
. 2024 Oct;
7(1):1340.
PMID: 39414943
Formalin-fixed paraffin-embedded (FFPE) samples are valuable but underutilized in single-cell omics research due to their low RNA quality. In this study, leveraging a recent advance in single-cell genomic technology, we...
3.
Chen J, Larsson L, Swarbrick A, Lundeberg J
Nat Rev Clin Oncol
. 2024 Jul;
21(9):660-674.
PMID: 39043872
Solid tumours comprise many different cell types organized in spatially structured arrangements, with substantial intratumour and intertumour heterogeneity. Advances in spatial profiling technologies over the past decade hold promise to...
4.
Pereira B, Ritchie S, Chambers C, Gordon K, Magenau A, Murphy K, et al.
Sci Adv
. 2024 Jul;
10(27):eadl1197.
PMID: 38959305
Pancreatic ductal adenocarcinoma (PDAC) is characterized by increasing fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased temporal assessment of the matrisome of the highly metastatic...
5.
Quek C, Pratapa A, Bai X, Al-Eryani G, Pires da Silva I, Mayer A, et al.
Cell Rep
. 2024 Jun;
43(7):114392.
PMID: 38944836
Heterogeneous resistance to immunotherapy remains a major challenge in cancer treatment, often leading to disease progression and death. Using CITE-seq and matched 40-plex PhenoCycler tissue imaging, we performed longitudinal multimodal...
6.
Holliday H, Yang J, Dodson E, Nikolic I, Kamili A, Wheatley M, et al.
Mol Ther
. 2024 May;
32(6):2031-2033.
PMID: 38759647
No abstract available.
7.
Filipe E, Velayuthar S, Philp A, Nobis M, Latham S, Parker A, et al.
Adv Sci (Weinh)
. 2024 Apr;
11(23):e2307963.
PMID: 38602451
In recent decades, the role of tumor biomechanics on cancer cell behavior at the primary site has been increasingly appreciated. However, the effect of primary tumor biomechanics on the latter...
8.
Meyer B, Stirzaker C, Ramkomuth S, Harvey K, Chan B, Lee C, et al.
J Pathol
. 2024 Feb;
262(4):480-494.
PMID: 38300122
Phyllodes tumours (PTs) are rare fibroepithelial lesions of the breast that are classified as benign, borderline, or malignant. As little is known about the molecular underpinnings of PTs, current diagnosis...
9.
Ciriello G, Magnani L, Aitken S, Akkari L, Behjati S, Hanahan D, et al.
Cancer Discov
. 2023 Dec;
14(1):36-48.
PMID: 38047596
Significance: Tumor evolution is fueled by multiple enabling mechanisms. Importantly, genetic instability, epigenetic reprogramming, and interactions with the tumor microenvironment are neither alternative nor independent evolutionary mechanisms. As demonstrated by...
10.
Zhai L, Balachandran A, Larkin R, Seneviratne J, Chung S, Lalwani A, et al.
Int J Mol Sci
. 2023 Nov;
24(21).
PMID: 37958555
amplification occurs in approximately 20-30% of neuroblastoma patients and correlates with poor prognosis. The transgenic mouse model mimics the development of human high-risk neuroblastoma and provides strong evidence for the...