Simon Bornschein
Overview
Explore the profile of Simon Bornschein including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
363
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Recent Articles
1.
Lampi Y, Van Looveren D, Vranckx L, Thiry I, Bornschein S, Debyser Z, et al.
Sci Rep
. 2019 Feb;
9(1):2389.
PMID: 30787394
To fulfill a productive infection cycle the human immunodeficiency virus (HIV) relies on host-cell factors. Interference with these co-factors holds great promise in protecting cells against HIV infection. LEDGF/p75, encoded...
2.
Brajic A, Franckaert D, Burton O, Bornschein S, Calvanese A, Demeyer S, et al.
Front Immunol
. 2018 Oct;
9:1989.
PMID: 30319599
Mammalian genomes encode a plethora of long non-coding RNA (lncRNA). These transcripts are thought to regulate gene expression, influencing biological processes from development to pathology. Results from the few lncRNA...
3.
Vanden Bempt M, Demeyer S, Broux M, De Bie J, Bornschein S, Mentens N, et al.
Cancer Cell
. 2018 Aug;
34(2):271-285.e7.
PMID: 30107177
The NUP214-ABL1 fusion is a constitutively activated tyrosine kinase that is significantly associated with overexpression of the TLX1 and TLX3 transcription factors in T cell acute lymphoblastic leukemia (T-ALL). Here...
4.
Baens M, Stirparo R, Lampi Y, Verbeke D, Vandepoel R, Cools J, et al.
Eur J Immunol
. 2018 Jul;
48(10):1728-1738.
PMID: 30025160
Mucosa-associated lymphoid tissue 1 (Malt1) regulates immune cell function by mediating the activation of nuclear factor κB (NF-κB) signaling through both its adaptor and proteolytic function. Malt1 is also a...
5.
Verboom K, Van Loocke W, Volders P, Decaesteker B, Avila Cobos F, Bornschein S, et al.
Haematologica
. 2018 Jun;
103(12):e585-e589.
PMID: 29954933
No abstract available.
6.
de Bock C, Demeyer S, Degryse S, Verbeke D, Sweron B, Gielen O, et al.
Cancer Discov
. 2018 Mar;
8(5):616-631.
PMID: 29496663
Leukemia is caused by the accumulation of multiple genomic lesions in hematopoietic precursor cells. However, how these events cooperate during oncogenic transformation remains poorly understood. We studied the cooperation between...
7.
Degryse S, Bornschein S, de Bock C, Leroy E, Vanden Bempt M, Demeyer S, et al.
Blood
. 2017 Dec;
131(4):421-425.
PMID: 29187379
The Janus kinase 3 (JAK3) tyrosine kinase is mutated in 10% to 16% of T-cell acute lymphoblastic leukemia (T-ALL) cases. JAK3 mutants induce constitutive JAK/STAT signaling and cause leukemia when...
8.
Humblet-Baron S, Franckaert D, Dooley J, Bornschein S, Cauwe B, Schonefeldt S, et al.
J Allergy Clin Immunol
. 2016 Mar;
138(1):200-209.e8.
PMID: 26947179
Background: Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition driven by excessive CD8(+) T-cell activation. HLH occurs as both acquired and familial hemophagocytic lymphohistiocytosis (FHL) forms. In both conditions, a...
9.
Van Eyck L, De Somer L, Pombal D, Bornschein S, Frans G, Humblet-Baron S, et al.
Arthritis Rheumatol
. 2015 Mar;
67(6):1592-7.
PMID: 25777993
Objective: To identify the underlying genetic defect in a 16-year-old girl with severe early-onset and refractory systemic lupus erythematosus (SLE), IgA deficiency, and mild lower limb spasticity without neuroradiologic manifestations....
10.
Brain O, Owens B, Pichulik T, Allan P, Khatamzas E, Leslie A, et al.
Immunity
. 2013 Sep;
39(3):521-36.
PMID: 24054330
NOD2 is an intracellular sensor that contributes to immune defense and inflammation. Here we investigated whether NOD2 mediates its effects through control of microRNAs (miRNAs). miR-29 expression was upregulated in...