Marlies Vanden Bempt
Overview
Explore the profile of Marlies Vanden Bempt including associated specialties, affiliations and a list of published articles.
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10
Citations
787
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Recent Articles
1.
Vanden Bempt M, Debackere K, Demeyer S, Van Thillo Q, Meeuws N, Prieto C, et al.
Blood
. 2022 Aug;
140(23):2463-2476.
PMID: 35960849
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of hematological cancers arising from the malignant transformation of mature T cells. In a cohort of 28 PTCL cases, we identified recurrent...
2.
Debackere K, Marcelis L, Demeyer S, Vanden Bempt M, Mentens N, Gielen O, et al.
Nat Commun
. 2021 Jun;
12(1):3705.
PMID: 34140493
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas with poor prognosis. Up to 30% of PTCL lack distinctive features and are classified as PTCL, not otherwise specified...
3.
Bassez A, Vos H, Van Dyck L, Floris G, Arijs I, Desmedt C, et al.
Nat Med
. 2021 May;
27(5):820-832.
PMID: 33958794
Immune-checkpoint blockade (ICB) combined with neoadjuvant chemotherapy improves pathological complete response in breast cancer. To understand why only a subset of tumors respond to ICB, patients with hormone receptor-positive or...
4.
A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling
Qian J, Olbrecht S, Boeckx B, Vos H, Laoui D, Etlioglu E, et al.
Cell Res
. 2020 Jun;
30(9):745-762.
PMID: 32561858
The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells, which are profoundly moulded by cancer cells. An outstanding question is to what...
5.
Vanden Bempt M, Mentens N, Vandenberghe P, Cools J, De Keersmaecker K
Hemasphere
. 2019 Nov;
2(2):e32.
PMID: 31723760
Supplemental Digital Content is available in the text.
6.
Broux M, Prieto C, Demeyer S, Vanden Bempt M, Alberti-Servera L, Lodewijckx I, et al.
Blood
. 2019 Sep;
134(16):1323-1336.
PMID: 31492675
The polycomb repressive complex 2, with core components EZH2, SUZ12, and EED, is responsible for writing histone 3 lysine 27 trimethylation histone marks associated with gene repression. Analysis of sequence...
7.
Vanden Bempt M, Demeyer S, Broux M, De Bie J, Bornschein S, Mentens N, et al.
Cancer Cell
. 2018 Aug;
34(2):271-285.e7.
PMID: 30107177
The NUP214-ABL1 fusion is a constitutively activated tyrosine kinase that is significantly associated with overexpression of the TLX1 and TLX3 transcription factors in T cell acute lymphoblastic leukemia (T-ALL). Here...
8.
de Bock C, Demeyer S, Degryse S, Verbeke D, Sweron B, Gielen O, et al.
Cancer Discov
. 2018 Mar;
8(5):616-631.
PMID: 29496663
Leukemia is caused by the accumulation of multiple genomic lesions in hematopoietic precursor cells. However, how these events cooperate during oncogenic transformation remains poorly understood. We studied the cooperation between...
9.
Degryse S, Bornschein S, de Bock C, Leroy E, Vanden Bempt M, Demeyer S, et al.
Blood
. 2017 Dec;
131(4):421-425.
PMID: 29187379
The Janus kinase 3 (JAK3) tyrosine kinase is mutated in 10% to 16% of T-cell acute lymphoblastic leukemia (T-ALL) cases. JAK3 mutants induce constitutive JAK/STAT signaling and cause leukemia when...
10.
van der Krogt J, Vanden Bempt M, Ferreiro J, Mentens N, Jacobs K, Pluys U, et al.
Haematologica
. 2017 Jun;
102(9):1605-1616.
PMID: 28659337
Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma is characterized by 2p23/ aberrations, including the classic t(2;5)(p23;q35)/ rearrangement present in ~80% of cases and several variant t(2p23/ALK) occurring in the...