Silvina A Fratantoni
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Explore the profile of Silvina A Fratantoni including associated specialties, affiliations and a list of published articles.
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10
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357
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Recent Articles
1.
Schouten M, Bielefeld P, Fratantoni S, Hubens C, Piersma S, Pham T, et al.
Sci Data
. 2016 Aug;
3:160068.
PMID: 27529540
Temporal lobe epilepsy (TLE) can develop from alterations in hippocampal structure and circuit characteristics, and can be modeled in mice by administration of kainic acid (KA). Adult neurogenesis in the...
2.
Schouten M, Fratantoni S, Hubens C, Piersma S, Pham T, Bielefeld P, et al.
Sci Rep
. 2015 Jul;
5:12448.
PMID: 26207921
Adult neurogenesis continuously contributes new neurons to hippocampal circuits and the programmed death of a subset of immature cells provides a primary mechanism controlling this contribution. Epileptic seizures induce strong...
3.
Lu X, Mattis V, Wang N, Al-Ramahi I, van den Berg N, Fratantoni S, et al.
Sci Transl Med
. 2014 Dec;
6(268):268ra178.
PMID: 25540325
Age-related neurodegenerative disorders including Alzheimer's disease and Huntington's disease (HD) consistently show elevated DNA damage, but the relevant molecular pathways in disease pathogenesis remain unclear. One attractive gene is that...
4.
Todd D, Gowers I, Dowler S, Wall M, McAllister G, Fischer D, et al.
PLoS One
. 2014 Feb;
9(2):e87923.
PMID: 24503862
Huntington's disease (HD) is a devastating, genetic neurodegenerative disease caused by a tri-nucleotide expansion in exon 1 of the huntingtin gene. HD is clinically characterized by chorea, emotional and psychiatric...
5.
van Dijk K, Berendse H, Drukarch B, Fratantoni S, Pham T, Piersma S, et al.
Brain Pathol
. 2011 Oct;
22(4):485-98.
PMID: 21988495
The locus ceruleus is among the earliest affected brain regions in Parkinson's disease (PD) showing Lewy body pathology and neuronal loss. To improve our understanding of the pathogenesis of PD,...
6.
Fratantoni S, Piersma S, Jimenez C
Proteomics Clin Appl
. 2010 Dec;
4(6-7):613-7.
PMID: 21137079
Purpose: For biomarker discovery in cerebrospinal fluid (CSF), removal of major serum proteins is advantageous as more CSF proteins including brain-derived proteins can be identified. Our goal was to create...
7.
Vischer H, Hulshof J, Hulscher S, Fratantoni S, Verheij M, Victorina J, et al.
Bioorg Med Chem
. 2009 Dec;
18(2):675-88.
PMID: 20031418
Human cytomegalovirus (HCMV) is a widespread human pathogen, possessing onco-modulatory properties. Constitutive signaling of the HCMV-encoded chemokine receptor US28 and its ability to bind a broad spectrum of chemokines might...
8.
van Dijk F, Nesbitt I, Zwikstra E, Nikkels P, Piersma S, Fratantoni S, et al.
Am J Hum Genet
. 2009 Sep;
85(4):521-7.
PMID: 19781681
Deficiency of cartilage-associated protein (CRTAP) or prolyl 3-hydroxylase 1(P3H1) has been reported in autosomal-recessive lethal or severe osteogenesis imperfecta (OI). CRTAP, P3H1, and cyclophilin B (CyPB) form an intracellular collagen-modifying...
9.
Hulshof J, Vischer H, Verheij M, Fratantoni S, Smit M, de Esch I, et al.
Bioorg Med Chem
. 2006 Jul;
14(21):7213-30.
PMID: 16843661
G-protein coupled receptors encoded by viruses represent an unexplored class of potential drug targets. In this study, we describe the synthesis and pharmacological characterization of the first class of inverse...
10.
Kitbunnadaj R, Hoffmann M, Fratantoni S, Bongers G, Bakker R, Wieland K, et al.
Bioorg Med Chem
. 2005 Oct;
13(23):6309-23.
PMID: 16213736
In this study, we replaced the basic amine function of the known histamine H(3) receptor agonists imbutamine or immepip with non-basic alcohol or hydrocarbon moieties. All compounds in this study...