Mark H P Verheij
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Explore the profile of Mark H P Verheij including associated specialties, affiliations and a list of published articles.
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8
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67
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Recent Articles
1.
Thompson A, Verheij M, Verbeek J, Windhorst A, de Esch I, Lummis S
Neuropharmacology
. 2014 Sep;
86:378-88.
PMID: 25174552
VUF10166 (2-chloro-3-(4-methyl piperazin-1-yl)quinoxaline) is a ligand that binds with high affinity to 5-HT3 receptors. Here we synthesise [(3)H]VUF10166 and characterise its binding properties at 5-HT3A and 5-HT3AB receptors. At 5-HT3A...
2.
Thompson A, Verheij M, van Muijlwijk-Koezen J, Lummis S, Leurs R, de Esch I
ChemMedChem
. 2013 May;
8(6):946-55.
PMID: 23640722
Until recently, discriminating between homomeric 5-HT3A and heteromeric 5-HT3AB receptors was only possible with ligands that bind in the receptor pore. This study describes the first series of ligands that...
3.
de Graaf C, Vischer H, De Kloe G, Kooistra A, Nijmeijer S, Kuijer M, et al.
Drug Discov Today
. 2012 Dec;
18(7-8):323-30.
PMID: 23266367
Smaller stones with a wide variety of colors make a higher resolution mosaic. In much the same way, smaller chemical entities that are structurally diverse are better able to interrogate...
4.
Verheij M, Thompson A, van Muijlwijk-Koezen J, Lummis S, Leurs R, de Esch I
J Med Chem
. 2012 Sep;
55(20):8603-14.
PMID: 23006041
The 5-HT₃ receptor, a pentameric ligand-gated ion channel (pLGIC), is an important therapeutic target. During a recent fragment screen, 6-chloro-N-methyl-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine (1) was identified as a 5-HT₃ hit fragment. Here we...
5.
Verheij M, de Graaf C, De Kloe G, Nijmeijer S, Vischer H, Smits R, et al.
Bioorg Med Chem Lett
. 2011 Jul;
21(18):5460-4.
PMID: 21782429
A fragment library was screened against the G protein-coupled histamine H(4) receptor (H(4)R) and the ligand-gated ion channel serotonin 5-HT(3A) (5-HT(3A)R). Interestingly, significant overlap was found between H(4)R and 5-HT(3A)R...
6.
Thompson A, Verheij M, Leurs R, de Esch I, Lummis S
Biotechniques
. 2010 Nov;
49(5):822-9.
PMID: 21091447
Drug discovery requires a simple, rapid, and cost-effective method for the early identification of novel leads and elimination of poor candidates. Here we present an experimental design that fulfils these...
7.
Vischer H, Hulshof J, Hulscher S, Fratantoni S, Verheij M, Victorina J, et al.
Bioorg Med Chem
. 2009 Dec;
18(2):675-88.
PMID: 20031418
Human cytomegalovirus (HCMV) is a widespread human pathogen, possessing onco-modulatory properties. Constitutive signaling of the HCMV-encoded chemokine receptor US28 and its ability to bind a broad spectrum of chemokines might...
8.
Hulshof J, Vischer H, Verheij M, Fratantoni S, Smit M, de Esch I, et al.
Bioorg Med Chem
. 2006 Jul;
14(21):7213-30.
PMID: 16843661
G-protein coupled receptors encoded by viruses represent an unexplored class of potential drug targets. In this study, we describe the synthesis and pharmacological characterization of the first class of inverse...