Silvia Santamarina-Fojo
Overview
Explore the profile of Silvia Santamarina-Fojo including associated specialties, affiliations and a list of published articles.
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24
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812
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Recent Articles
1.
Amar M, Shamburek R, Vaisman B, Knapper C, Foger B, Hoyt Jr R, et al.
Metabolism
. 2009 Mar;
58(4):568-75.
PMID: 19303980
Lecithin-cholesterol acyltransferase (LCAT), a key enzyme in high-density lipoprotein (HDL) metabolism, has been proposed to have atheroprotective properties by promoting reverse cholesterol transport. Overexpression of LCAT in various animal models,...
2.
Guo G, Santamarina-Fojo S, Akiyama T, Amar M, Paigen B, Brewer Jr B, et al.
Biochim Biophys Acta
. 2006 Nov;
1761(12):1401-9.
PMID: 17110163
Farnesoid X receptor (FXR), a bile-acid-activated member of the nuclear receptor superfamily, is essential in regulating bile-acid, cholesterol, and triglyceride homeostasis. Disruption of the FXR gene in mice results in...
3.
Freeman L, Amar M, Shamburek R, Paigen B, Brewer Jr H, Santamarina-Fojo S, et al.
J Lipid Res
. 2006 Oct;
48(1):104-13.
PMID: 17071916
To elucidate the separate contributions of the lipolytic versus ligand-binding functions of hepatic lipase (HL) to lipoprotein metabolism and atherosclerosis, and to investigate the role of the low density lipoprotein...
4.
Basso F, Amar M, Wagner E, Vaisman B, Paigen B, Santamarina-Fojo S, et al.
Biochem Biophys Res Commun
. 2006 Oct;
351(2):398-404.
PMID: 17070501
ABCG1 promotes cholesterol efflux from cells, but ABCG1(-/-) bone marrow transplant into ApoE(-/-) and LDLr(-/-) mice reduces atherosclerosis. To further investigate the role of ABCG1 in atherosclerosis, ABCG1 transgenic mice...
5.
Basso F, Freeman L, Ko C, Joyce C, Amar M, Shamburek R, et al.
J Lipid Res
. 2006 Oct;
48(1):114-26.
PMID: 17060690
We previously reported that liver-specific overexpression of ABCG5/G8 in mice is not atheroprotective, suggesting that increased biliary cholesterol secretion must be coupled with decreased intestinal cholesterol absorption to increase net...
6.
Joyce C, Wagner E, Basso F, Amar M, Freeman L, Shamburek R, et al.
J Biol Chem
. 2006 Aug;
281(44):33053-65.
PMID: 16928680
The identification of ABCA1 as a key transporter responsible for cellular lipid efflux has led to considerable interest in defining its role in cholesterol metabolism and atherosclerosis. In this study,...
7.
Sabol S, Brewer Jr H, Santamarina-Fojo S
J Lipid Res
. 2005 Jul;
46(10):2151-67.
PMID: 16024918
The ABC transporter ABCG1 (ATP binding cassette transporter G1), expressed in macrophages, liver, and other tissues, has been implicated in the efflux of cholesterol to high density lipoprotein. The ABCG1...
8.
Gonzalez-Navarro H, Nong Z, Amar M, Shamburek R, Najib-Fruchart J, Paigen B, et al.
J Biol Chem
. 2004 Aug;
279(44):45312-21.
PMID: 15304509
To investigate the separate contributions of the lipolytic versus ligand-binding function of hepatic lipase (HL) to plasma lipoprotein metabolism and atherosclerosis, we compared mice expressing catalytically active wild-type HL (HL-WT)...
9.
Santamarina-Fojo S, Gonzalez-Navarro H, Freeman L, Wagner E, Nong Z
Arterioscler Thromb Vasc Biol
. 2004 Jul;
24(10):1750-4.
PMID: 15284087
The role of hepatic lipase as a multifunctional protein that modulates lipoprotein metabolism and atherosclerosis has been extensively documented over the last decade. Hepatic lipase functions as a lipolytic enzyme...
10.
Freeman L, Kennedy A, Wu J, Bark S, Remaley A, Santamarina-Fojo S, et al.
J Lipid Res
. 2004 May;
45(7):1197-206.
PMID: 15121760
The ATP binding cassette (ABC) half-transporters ABCG5 and ABCG8 facilitate biliary and intestinal removal of neutral sterols. Here, we identify a binding site for the orphan nuclear receptor liver receptor...