Lita Freeman
Overview
Explore the profile of Lita Freeman including associated specialties, affiliations and a list of published articles.
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20
Citations
572
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Recent Articles
1.
Sorokin A, Karathanasis S, Yang Z, Freeman L, Kotani K, Remaley A
FASEB J
. 2020 Jun;
34(8):9843-9853.
PMID: 32588493
The current coronavirus disease 2019 (COVID-19) pandemic presents a global challenge for managing acutely ill patients and complications from viral infection. Systemic inflammation accompanied by a "cytokine storm," hemostasis alterations...
2.
Ueda M, Dunbar R, Wolska A, Sikora T, Escobar M, Seliktar N, et al.
J Clin Endocrinol Metab
. 2017 Feb;
102(5):1454-1457.
PMID: 28201738
Context: Familial chylomicronemia syndrome (FCS) is a rare heritable disorder associated with severe hypertriglyceridemia and recurrent pancreatitis. Lipoprotein lipase deficiency and apolipoprotein C-II deficiency are two well-characterized autosomal recessive causes...
3.
Lucero D, Sviridov D, Svidirov D, Freeman L, Lopez G, Fassio E, et al.
Atherosclerosis
. 2015 Aug;
242(1):236-42.
PMID: 26232163
Background: Metabolic syndrome (MetS) is associated with changes in HDL levels, composition and sub-fraction profile. Whether these alterations affect HDL anti-atherogenic function, specifically measured as its capacity to perform cholesterol...
4.
Schwendeman A, Sviridov D, Yuan W, Guo Y, Morin E, Yuan Y, et al.
J Lipid Res
. 2015 Jun;
56(9):1727-37.
PMID: 26117661
The goal of this study was to understand how the reconstituted HDL (rHDL) phospholipid (PL) composition affects its cholesterol efflux and anti-inflammatory properties. An ApoA-I mimetic peptide, 5A, was combined...
5.
Thacker S, Rousset X, Esmail S, Zarzour A, Jin X, Collins H, et al.
J Lipid Res
. 2015 May;
56(7):1282-95.
PMID: 25964513
LCAT, a plasma enzyme that esterifies cholesterol, has been proposed to play an antiatherogenic role, but animal and epidemiologic studies have yielded conflicting results. To gain insight into LCAT and...
6.
Amar M, Sakurai T, Sakurai-Ikuta A, Sviridov D, Freeman L, Ahsan L, et al.
J Pharmacol Exp Ther
. 2014 Nov;
352(2):227-35.
PMID: 25395590
Apolipoprotein A-I (apoA-I) mimetic peptides are currently being developed as possible new agents for the treatment of cardiovascular disease based on their ability to promote cholesterol efflux and their other...
7.
Stukas S, Freeman L, Lee M, Wilkinson A, Ossoli A, Vaisman B, et al.
J Lipid Res
. 2014 Jun;
55(8):1721-9.
PMID: 24950691
A key step in plasma HDL maturation from discoidal to spherical particles is the esterification of cholesterol to cholesteryl ester, which is catalyzed by LCAT. HDL-like lipoproteins in cerebrospinal fluid...
8.
Belfer I, Youngblood V, Darbari D, Wang Z, Diaw L, Freeman L, et al.
Am J Hematol
. 2013 Oct;
89(2):187-93.
PMID: 24136375
GTP cyclohydrolase (GCH1) is rate limiting for tetrahydrobiopterin (BH4) synthesis, where BH4 is a cofactor for nitric oxide (NO) synthases and aromatic hydroxylases. GCH1 polymorphisms are implicated in the pathophysiology...
9.
Vazquez E, Sethi A, Freeman L, Zalos G, Chaudhry H, Haser E, et al.
Am J Cardiol
. 2011 Nov;
109(4):527-32.
PMID: 22105786
Subjects at risk of atherosclerosis might have dysfunctional high-density lipoprotein (HDL) despite normal cholesterol content in the plasma. We considered whether the efflux of excess cellular cholesterol to HDL from...
10.
Tumblin A, Tailor A, Hoehn G, Mack A, Mendelsohn L, Freeman L, et al.
Haematologica
. 2010 Apr;
95(9):1467-72.
PMID: 20378559
Background: Acute painful episodes are the clinical hallmark of sickle cell disease and have been linked to morbidity and mortality in the sickle cell population. Design And Methods: We undertook...