Edward B Neufeld
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Explore the profile of Edward B Neufeld including associated specialties, affiliations and a list of published articles.
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32
Citations
500
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Recent Articles
1.
Reimund M, Dearborn A, Graziano G, Lei H, Ciancone A, Kumar A, et al.
Nature
. 2024 Dec;
638(8051):829-835.
PMID: 39663455
Apolipoprotein B100 (apoB100) is a structural component of low-density lipoprotein (LDL) and a ligand for the LDL receptor (LDLR). Mutations in apoB100 or in LDLR cause familial hypercholesterolaemia, an autosomal...
2.
Sato M, Hamasaki M, Neufeld E, Remaley A, Kotani K
Ann Clin Lab Sci
. 2024 Jul;
54(3):419-422.
PMID: 39048165
Objective: Familial hypercholesterolemia (FH) is characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD). Although the role of LDL-C in FH has been studied, the contribution...
3.
Zubiran R, Neufeld E, Dasseux A, Remaley A, Sorokin A
Cardiol Ther
. 2024 Jul;
13(3):465-491.
PMID: 39031302
Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality despite effective low-density lipoprotein cholesterol-targeted therapies. This review explores the crucial role of inflammation in the residual risk...
4.
Garcia E, Shalaurova I, Matyus S, Freeman L, Neufeld E, Sampson M, et al.
Molecules
. 2024 Feb;
29(3).
PMID: 38338310
Lipoprotein X (LP-X) is an abnormal cholesterol-rich lipoprotein particle that accumulates in patients with cholestatic liver disease and familial lecithin-cholesterol acyltransferase deficiency (FLD). Because there are no high-throughput diagnostic tests...
5.
Sato M, Neufeld E, Playford M, Lei Y, Sorokin A, Aponte A, et al.
J Clin Invest
. 2023 Jul;
133(18).
PMID: 37471145
BACKGROUNDCellular cholesterol efflux capacity (CEC) is a better predictor of cardiovascular disease (CVD) events than HDL-cholesterol (HDL-C) but is not suitable as a routine clinical assay.METHODSWe developed an HDL-specific phospholipid...
6.
Jeiran K, Gordon S, Sviridov D, Aponte A, Haymond A, Piszczek G, et al.
Int J Mol Sci
. 2022 Oct;
23(19).
PMID: 36232786
ApoB-100 is a member of a large lipid transfer protein superfamily and is one of the main apolipoproteins found on low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) particles. Despite...
7.
Neufeld E, Freeman L, Durbhakula V, Sampson M, Shamburek R, Karathanasis S, et al.
Biology (Basel)
. 2022 Aug;
11(8).
PMID: 36009874
Lipoprotein-X (LpX) are abnormal nephrotoxic lipoprotein particles enriched in free cholesterol and phospholipids. LpX with distinctive lipid compositions are formed in patients afflicted with either familial LCAT deficiency (FLD) or...
8.
Lucero D, Dikilitas O, Mendelson M, Aligabi Z, Islam P, Neufeld E, et al.
J Lipid Res
. 2021 Dec;
63(1):100160.
PMID: 34902367
A significant proportion of patients with elevated LDL and a clinical presentation of familial hypercholesterolemia do not carry known genetic mutations associated with hypercholesterolemia, such as defects in the LDL...
9.
Amar M, Freeman L, Nishida T, Sampson M, Pryor M, Vaisman B, et al.
Pharmacol Res Perspect
. 2020 Jan;
8(1):e00554.
PMID: 31893124
Familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is a rare genetic disease characterized by low HDL-C levels, low plasma cholesterol esterification, and the formation of Lipoprotein-X (Lp-X), an abnormal cholesterol-rich lipoprotein...
10.
Neufeld E, Sato M, Gordon S, Durbhakula V, Francone N, Aponte A, et al.
Biology (Basel)
. 2019 Jul;
8(3).
PMID: 31336888
We describe simple, sensitive and robust methods to monitor lipoprotein remodeling and cholesterol and apolipoprotein exchange, using fluorescent Lissamine Rhodamine B head-group tagged phosphatidylethanolamine (*PE) as a lipoprotein reference marker....