Silvia Paoletta
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Explore the profile of Silvia Paoletta including associated specialties, affiliations and a list of published articles.
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41
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1032
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Recent Articles
11.
Jacobson K, Gao Z, Paoletta S, Kiselev E, Chakraborty S, Jayasekara P, et al.
Comput Struct Biotechnol J
. 2015 May;
13:286-98.
PMID: 25973142
We establish structure activity relationships of extracellular nucleosides and nucleotides at G protein-coupled receptors (GPCRs), e.g. adenosine receptors (ARs) and P2Y receptors (P2YRs), respectively. We synthesize selective agents for use...
12.
Trujillo K, Paoletta S, Kiselev E, Jacobson K
Bioorg Med Chem
. 2015 Apr;
23(14):4056-64.
PMID: 25868749
The P2Y14 receptor (P2Y14R) is a Gi protein-coupled receptor that is activated by uracil nucleotides UDP and UDP-glucose. The P2Y14R structure has yet to be solved through X-ray crystallography, but...
13.
Jacobson K, Paoletta S, Katritch V, Wu B, Gao Z, Zhao Q, et al.
Mol Pharmacol
. 2015 Apr;
88(2):220-30.
PMID: 25837834
Eight G protein-coupled P2Y receptor (P2YR) subtypes are important physiologic mediators. The human P2YRs are fully activated by ATP (P2Y2 and P2Y11), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2 and...
14.
Zhang D, Gao Z, Zhang K, Kiselev E, Crane S, Wang J, et al.
Nature
. 2015 Mar;
520(7547):317-21.
PMID: 25822790
In response to adenosine 5'-diphosphate, the P2Y1 receptor (P2Y1R) facilitates platelet aggregation, and thus serves as an important antithrombotic drug target. Here we report the crystal structures of the human...
15.
Jacobson K, Costanzi S, Paoletta S
Trends Pharmacol Sci
. 2014 Dec;
35(12):658-63.
PMID: 25458540
Since G protein-coupled receptors (GPCRs) belong to a very large superfamily of evolutionarily related receptors (>800 members in humans), and due to the rapid progress on their structural biology, they...
16.
Lecchi A, Razzari C, Paoletta S, Dupuis A, Nakamura L, Ohlmann P, et al.
Blood
. 2014 Nov;
125(6):1006-13.
PMID: 25428217
Defects of the platelet P2Y12 receptor (P2Y12R) for adenosine diphosphate (ADP) are associated with increased bleeding risk. The study of molecular abnormalities associated with inherited qualitative defects of the P2Y12R...
17.
Tosh D, Finley A, Paoletta S, Moss S, Gao Z, Gizewski E, et al.
J Med Chem
. 2014 Nov;
57(23):9901-14.
PMID: 25422861
(N)-Methanocarba adenosine 5'-methyluronamides containing 2-arylethynyl groups were synthesized as A3 adenosine receptor (AR) agonists and screened in vivo (po) for reduction of neuropathic pain. A small N(6)-methyl group maintained binding...
18.
Kiselev E, Barrett M, Katritch V, Paoletta S, Weitzer C, Brown K, et al.
ACS Chem Biol
. 2014 Oct;
9(12):2833-42.
PMID: 25299434
The P2Y14 receptor (P2Y14R), one of eight P2Y G protein-coupled receptors (GPCR), is involved in inflammatory, endocrine, and hypoxic processes and is an attractive pharmaceutical target. The goal of this...
19.
Bahamonde M, Taura J, Paoletta S, Gakh A, Chakraborty S, Hernando J, et al.
Bioconjug Chem
. 2014 Sep;
25(10):1847-54.
PMID: 25248077
The adenosinergic system operates through G protein-coupled adenosine receptors, which have become promising therapeutic targets for a wide range of pathological conditions. However, the ubiquity of adenosine receptors and the...
20.
Moss S, Jayasekara P, Paoletta S, Gao Z, Jacobson K
ACS Med Chem Lett
. 2014 Sep;
5(9):1043-8.
PMID: 25221664
Adenosine receptors (ARs) are members of the G protein-coupled receptor (GPCR) superfamily and have shown much promise as therapeutic targets. We have used an agonist-bound A2AAR X-ray crystallographic structure to...