Evgeny Kiselev
Overview
Explore the profile of Evgeny Kiselev including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
781
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Recent Articles
1.
Zhao X, Wang W, Lountos G, Kiselev E, Tropea J, Needle D, et al.
RSC Chem Biol
. 2023 May;
4(5):334-343.
PMID: 37181631
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a member of the phospholipase D family that can downregulate the anticancer effects of the type I topoisomerase (TOP1) inhibitors by hydrolyzing the 3'-phosphodiester bond...
2.
Takahashi D, Gadelle D, Agama K, Kiselev E, Zhang H, Yab E, et al.
Nat Commun
. 2022 Jan;
13(1):59.
PMID: 35013228
Eukaryotic topoisomerases I (TOP1) are ubiquitous enzymes removing DNA torsional stress. However, there is little data concerning the three-dimensional structure of TOP1 in the absence of DNA, nor how the...
3.
Zhao X, Kiselev E, Lountos G, Wang W, Tropea J, Needle D, et al.
Chem Sci
. 2021 Jun;
12(11):3876-3884.
PMID: 34163656
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a member of the phospholipase D family of enzymes, which catalyzes the removal of both 3'- and 5'-DNA phosphodiester adducts. Importantly, it is capable of...
4.
Kiselev E, Ravji A, Kankanala J, Xie J, Wang Z, Pommier Y
DNA Repair (Amst)
. 2019 Nov;
85:102747.
PMID: 31775111
Tyrosyl-DNA phosphodiesterase 2 (TDP2) is a DNA repair enzyme that removes 5'-phosphotyrosyl blockages resulting from topoisomerase II (TOP2)-DNA cleavage complexes trapped by TOP2 inhibitors. TDP2 is a logical target for...
5.
Lountos G, Zhao X, Kiselev E, Tropea J, Needle D, Pommier Y, et al.
Nucleic Acids Res
. 2019 Jun;
47(19):10134-10150.
PMID: 31199869
Tyrosyl DNA-phosphodiesterase I (TDP1) repairs type IB topoisomerase (TOP1) cleavage complexes generated by TOP1 inhibitors commonly used as anticancer agents. TDP1 also removes DNA 3' end blocking lesions generated by...
6.
Kankanala J, Ribeiro C, Kiselev E, Ravji A, Williams J, Xie J, et al.
J Med Chem
. 2019 Apr;
62(9):4669-4682.
PMID: 30998359
Topoisomerase II (TOP2) poisons as anticancer drugs work by trapping TOP2 cleavage complexes (TOP2cc) to generate DNA damage. Repair of such damage by tyrosyl DNA phosphodiesterase 2 (TDP2) could render...
7.
Zhang X, Wang H, Tang W, Zhang Y, Yang H, Hu D, et al.
J Med Chem
. 2018 Oct;
61(22):9908-9930.
PMID: 30336023
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a recently discovered enzyme repairing DNA lesions resulting from stalled topoisomerase IB (TOP1)-DNA covalent complex. Inhibiting TDP1 in conjunction with TOP1 inhibitors can boost the...
8.
Zhao X, Metifiot M, Kiselev E, Kessl J, Maddali K, Marchand C, et al.
Molecules
. 2018 Jul;
23(8).
PMID: 30049955
HIV-1 integrase (IN) inhibitors represent a new class of highly effective anti-AIDS therapeutics. Current FDA-approved IN strand transfer inhibitors (INSTIs) share a common mechanism of action that involves chelation of...
9.
Kiselev E, Dexheimer T, Marchand C, Huang S, Pommier Y
DNA Repair (Amst)
. 2018 May;
66-67:64-71.
PMID: 29747024
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an ubiquitous DNA repair enzyme present in yeast, plants and animals. It removes a broad range of blocking lesions at the ends of DNA breaks....
10.
Yu L, Hu Z, Chen Y, Ravji A, Lopez S, Plescia C, et al.
Eur J Med Chem
. 2018 Apr;
151:777-796.
PMID: 29677635
Tyrosyl-DNA phosphodiesterase 2 (TDP2) is a recently discovered enzyme specifically repairing topoisomerase II (TOP2)-mediated DNA damage. It has been shown that inhibition of TDP2 synergize with TOP2 inhibitors. Herein, we...