Sigrun M Gustafsdottir
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Explore the profile of Sigrun M Gustafsdottir including associated specialties, affiliations and a list of published articles.
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14
Citations
886
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Recent Articles
1.
Bray M, Gustafsdottir S, Rohban M, Singh S, Ljosa V, Sokolnicki K, et al.
Gigascience
. 2017 Mar;
6(12):1-5.
PMID: 28327978
Background: Large-scale image sets acquired by automated microscopy of perturbed samples enable a detailed comparison of cell states induced by each perturbation, such as a small molecule from a diverse...
2.
Bray M, Singh S, Han H, Davis C, Borgeson B, Hartland C, et al.
Nat Protoc
. 2016 Aug;
11(9):1757-74.
PMID: 27560178
In morphological profiling, quantitative data are extracted from microscopy images of cells to identify biologically relevant similarities and differences among samples based on these profiles. This protocol describes the design...
3.
Blokzijl A, Chen L, Gustafsdottir S, Vuu J, Ullenhag G, Kampe O, et al.
PLoS One
. 2016 Apr;
11(4):e0154214.
PMID: 27110718
Background: The diagnosis of malignant melanoma currently relies on clinical inspection of the skin surface and on the histopathological status of the excised tumor. The serum marker S100B is used...
4.
Wawer M, Li K, Gustafsdottir S, Ljosa V, Bodycombe N, Marton M, et al.
Proc Natl Acad Sci U S A
. 2014 Jul;
111(30):10911-6.
PMID: 25024206
High-throughput screening has become a mainstay of small-molecule probe and early drug discovery. The question of how to build and evolve efficient screening collections systematically for cell-based and biochemical screening...
5.
Gustafsdottir S, Ljosa V, Sokolnicki K, Wilson J, Walpita D, Kemp M, et al.
PLoS One
. 2013 Dec;
8(12):e80999.
PMID: 24312513
Computational methods for image-based profiling are under active development, but their success hinges on assays that can capture a wide range of phenotypes. We have developed a multiplex cytological profiling...
6.
Sigurdsson V, Ingthorsson S, Hilmarsdottir B, Gustafsdottir S, Franzdottir S, Arason A, et al.
PLoS One
. 2013 Apr;
8(4):e60798.
PMID: 23573284
Branching morphogenesis is a mechanism used by many species for organogenesis and tissue maintenance. Receptor tyrosine kinases (RTKs), including epidermal growth factor receptor (EGFR) and the sprouty protein family are...
7.
Niklasson M, Bergstrom T, Zhang X, Gustafsdottir S, Sjogren M, Edqvist P, et al.
Exp Cell Res
. 2010 Jul;
316(17):2779-89.
PMID: 20643125
Platelet-derived growth factor (PDGF) is important in central nervous system (CNS) development, and aberrant expression of PDGF and its receptors has been linked to developmental defects and brain tumorigenesis. We...
8.
Gustafsdottir S, Wennstrom S, Fredriksson S, Schallmeiner E, Hamilton A, Sebti S, et al.
Clin Chem
. 2008 May;
54(7):1218-25.
PMID: 18499900
Background: Improved methods are required to screen drug candidates for their influences on protein interactions. There is also a compelling need for miniaturization of screening assays, with attendant reductions in...
9.
Nordengrahn A, Gustafsdottir S, Ebert K, Reid S, King D, Ferris N, et al.
Vet Microbiol
. 2007 Sep;
127(3-4):227-36.
PMID: 17897794
A novel proximity ligation assay (PLA) using a pan-serotype reactive monoclonal antibody was developed and evaluated for the detection of foot-and-mouth disease virus (FMDV) in clinical samples collected from field...
10.
Gustafsdottir S, Schlingemann J, Rada-Iglesias A, Schallmeiner E, Kamali-Moghaddam M, Wadelius C, et al.
Proc Natl Acad Sci U S A
. 2007 Mar;
104(9):3067-72.
PMID: 17360610
Protein-binding DNA sequence elements encode a variety of regulated functions of genomes. Information about such elements is currently in a state of rapid growth, but improved methods are required to...