Mark-Anthony Bray
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Explore the profile of Mark-Anthony Bray including associated specialties, affiliations and a list of published articles.
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41
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2431
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Recent Articles
1.
Thomas J, Shelton 4th C, Murphy J, Brittain S, Bray M, Aspesi P, et al.
ACS Chem Biol
. 2024 Apr;
19(4):938-952.
PMID: 38565185
Phenotypic assays have become an established approach to drug discovery. Greater disease relevance is often achieved through cellular models with increased complexity and more detailed readouts, such as gene expression...
2.
deletion in human pluripotent stem cells increases differentiation yield and maturity of neutrophils
Harper T, Oberlick E, Smith T, Nunes D, Bray M, Park S, et al.
iScience
. 2023 Sep;
26(10):107804.
PMID: 37720099
Human pluripotent stem cell (hPSC)-derived tissues can be used to model diseases in cell types that are challenging to harvest and study at-scale, such as neutrophils. Neutrophil dysregulation, specifically neutrophil...
3.
Caicedo J, Arevalo J, Piccioni F, Bray M, Hartland C, Wu X, et al.
Mol Biol Cell
. 2022 Mar;
33(6):ar49.
PMID: 35353015
Most variants in most genes across most organisms have an unknown impact on the function of the corresponding gene. This gap in knowledge is especially acute in cancer, where clinical...
4.
Shlevkov E, Basu H, Bray M, Sun Z, Wei W, Apaydin K, et al.
Cell Rep
. 2019 Sep;
28(12):3224-3237.e5.
PMID: 31533043
Dysregulated axonal trafficking of mitochondria is linked to neurodegenerative disorders. We report a high-content screen for small-molecule regulators of the axonal transport of mitochondria. Six compounds enhanced mitochondrial transport in...
5.
Bray M, Carpenter A
Methods Mol Biol
. 2017 Oct;
1683:89-112.
PMID: 29082489
Robust high-content screening of visual cellular phenotypes has been enabled by automated microscopy and quantitative image analysis. The identification and removal of common image-based aberrations is critical to the screening...
6.
Hulshof F, Papenburg B, Vasilevich A, Hulsman M, Zhao Y, Levers M, et al.
Biomaterials
. 2017 May;
137:49-60.
PMID: 28535442
Stem cells respond to the physicochemical parameters of the substrate on which they grow. Quantitative material activity relationships - the relationships between substrate parameters and the phenotypes they induce -...
7.
Barczak A, Avraham R, Singh S, Luo S, Zhang W, Bray M, et al.
PLoS Pathog
. 2017 May;
13(5):e1006363.
PMID: 28505176
A key to the pathogenic success of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is the capacity to survive within host macrophages. Although several factors required for this survival...
8.
Bray M, Gustafsdottir S, Rohban M, Singh S, Ljosa V, Sokolnicki K, et al.
Gigascience
. 2017 Mar;
6(12):1-5.
PMID: 28327978
Background: Large-scale image sets acquired by automated microscopy of perturbed samples enable a detailed comparison of cell states induced by each perturbation, such as a small molecule from a diverse...
9.
Rohban M, Singh S, Wu X, Berthet J, Bray M, Shrestha Y, et al.
Elife
. 2017 Mar;
6.
PMID: 28315521
We hypothesized that human genes and disease-associated alleles might be systematically functionally annotated using morphological profiling of cDNA constructs, via a microscopy-based Cell Painting assay. Indeed, 50% of the 220...
10.
Bray M, Singh S, Han H, Davis C, Borgeson B, Hartland C, et al.
Nat Protoc
. 2016 Aug;
11(9):1757-74.
PMID: 27560178
In morphological profiling, quantitative data are extracted from microscopy images of cells to identify biologically relevant similarities and differences among samples based on these profiles. This protocol describes the design...