Shushant Jain
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Explore the profile of Shushant Jain including associated specialties, affiliations and a list of published articles.
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22
Citations
2589
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Recent Articles
1.
Jayanth N, Mahe G, Campbell M, Lipkin M, Jain S, van de Bospoort R, et al.
SLAS Discov
. 2024 Dec;
30():100200.
PMID: 39638147
Ataxia Telangiectasia (A-T) is a rare, autosomal recessive genetic disorder characterized by a variety of symptoms, including progressive neurodegeneration, telangiectasia, immunodeficiency, and an increased susceptibility to cancer. It is caused...
2.
Haenig C, Atias N, Taylor A, Mazza A, Schaefer M, Russ J, et al.
Cell Rep
. 2020 Aug;
32(7):108050.
PMID: 32814053
Interactome maps are valuable resources to elucidate protein function and disease mechanisms. Here, we report on an interactome map that focuses on neurodegenerative disease (ND), connects ∼5,000 human proteins via...
3.
Jansen I, Ye H, Heetveld S, Lechler M, Michels H, Seinstra R, et al.
Genome Biol
. 2017 Feb;
18(1):22.
PMID: 28137300
Background: Whole-exome sequencing (WES) has been successful in identifying genes that cause familial Parkinson's disease (PD). However, until now this approach has not been deployed to study large cohorts of...
4.
Bettencourt C, Garcia de Yebenes J, Lopez-Sendon J, Shomroni O, Zhang X, Qian S, et al.
Cerebellum
. 2015 Jan;
14(3):378-81.
PMID: 25592071
No abstract available.
5.
Jain S, Van Kesteren R, Heutink P
J Vis Exp
. 2012 Jan;
(59):e3452.
PMID: 22257990
The functional annotation of genomes, construction of molecular networks and novel drug target identification, are important challenges that need to be addressed as a matter of great urgency. Multiple complementary...
6.
The complete automation of cell culture: improvements for high-throughput and high-content screening
Jain S, Sondervan D, Rizzu P, Bochdanovits Z, Caminada D, Heutink P
J Biomol Screen
. 2011 Jul;
16(8):932-9.
PMID: 21775700
Genomic approaches provide enormous amounts of raw data with regard to genetic variation, the diversity of RNA species, and protein complement. High-throughput (HT) and high-content (HC) cellular screens are ideally...
7.
van Abel D, Holzel D, Jain S, Lun F, Zheng Y, Chen E, et al.
PLoS One
. 2011 Jul;
6(7):e21994.
PMID: 21755018
Background: In this study, we performed a genome-wide search for effector genes bound by STOX1A, a winged helix transcription factor recently demonstrated to be involved in late onset Alzheimer's disease...
8.
Jain S, Heutink P
Neuron
. 2010 Oct;
68(2):207-17.
PMID: 20955929
Neuronal development, function, and the subsequent degeneration of the brain are still an enigma in both the normal and pathologic states, and there is an urgent need to find better...
9.
Greggio E, Zambrano I, Kaganovich A, Beilina A, Taymans J, Daniels V, et al.
J Biol Chem
. 2008 Apr;
283(24):16906-14.
PMID: 18397888
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and apparently sporadic Parkinson disease. LRRK2 is a multidomain protein kinase with autophosphorylation activity. It has previously...
10.
Johnson J, Paisan-Ruiz C, Lopez G, Crews C, Britton A, Malkani R, et al.
Neurodegener Dis
. 2007 Jul;
4(5):386-91.
PMID: 17622782
Background: Recently, mutations in LRRK2 encoding the protein dardarin have been linked to an autosomal dominant form of parkinsonism. Objective: To identify mutations causing Parkinson's disease (PD) in a cohort...