William P Gilks
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Explore the profile of William P Gilks including associated specialties, affiliations and a list of published articles.
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10
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3075
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Recent Articles
1.
Gilks W, Pennell T, Flis I, Webster M, Morrow E
F1000Res
. 2017 Jan;
5:2644.
PMID: 27928499
As part of a study into the molecular genetics of sexually dimorphic complex traits, we used high-throughput sequencing to obtain data on genomic variation in an outbred laboratory-adapted fruit fly...
2.
Gilks W, Abbott J, Morrow E
Trends Genet
. 2014 Sep;
30(10):453-63.
PMID: 25239223
Understanding the genetic architecture of disease is an enormous challenge, and should be guided by evolutionary principles. Recent studies in evolutionary genetics show that sexual selection can have a profound...
3.
Gilks W, Hill M, Gill M, Donohoe G, Corvin A, Morris D
World J Biol Psychiatry
. 2012 Mar;
13(7):550-4.
PMID: 22385474
Objectives: SNP rs2473277 upstream of the cell division cycle 42 (CDC42) gene was associated with schizophrenia in a recent genome-wide association study (GWAS). Reduced expression of CDC42 in schizophrenia has...
4.
Kenny E, Cormican P, Gilks W, Gates A, ODushlaine C, Pinto C, et al.
DNA Res
. 2010 Dec;
18(1):31-8.
PMID: 21163834
Screening large numbers of target regions in multiple DNA samples for sequence variation is an important application of next-generation sequencing but an efficient method to enrich the samples in parallel...
5.
Gilks W, Allott E, Donohoe G, Cummings E, Gill M, Corvin A, et al.
Neurosci Lett
. 2009 Nov;
468(3):229-33.
PMID: 19914345
Schizophrenia is a heritable mental disorder with a complex genetic aetiology potentially implicating glutamatergic dysfunction. Following a search for functionally relevant genes with evidence of linkage to schizophrenia, we selected...
6.
Muqit M, Abou-Sleiman P, Saurin A, Harvey K, Gandhi S, Deas E, et al.
J Neurochem
. 2006 Jun;
98(1):156-69.
PMID: 16805805
Following our identification of PTEN-induced putative kinase 1 (PINK1) gene mutations in PARK6-linked Parkinson's disease (PD), we have recently reported that PINK1 protein localizes to Lewy bodies (LBs) in PD...
7.
Khan N, Jain S, Lynch J, Pavese N, Abou-Sleiman P, Holton J, et al.
Brain
. 2005 Nov;
128(Pt 12):2786-96.
PMID: 16272164
We have established that the frequency of LRRK2 mutations in a series of 118 cases of familial Parkinson's disease is 5.1%. In the largest family with autosomal dominant, late-onset Parkinson's...
8.
Gilks W, Abou-Sleiman P, Gandhi S, Jain S, Singleton A, Lees A, et al.
Lancet
. 2005 Feb;
365(9457):415-6.
PMID: 15680457
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been shown to cause autosomal dominant Parkinson's disease. Few mutations in this gene have been identified. We investigated the frequency...
9.
Paisan-Ruiz C, Jain S, Evans E, Gilks W, Simon J, van der Brug M, et al.
Neuron
. 2004 Nov;
44(4):595-600.
PMID: 15541308
Parkinson's disease (PD; OMIM #168600) is the second most common neurodegenerative disorder in the Western world and presents as a progressive movement disorder. The hallmark pathological features of PD are...
10.
Valente E, Abou-Sleiman P, Caputo V, Muqit M, Harvey K, Gispert S, et al.
Science
. 2004 Apr;
304(5674):1158-60.
PMID: 15087508
Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigra. We previously mapped a locus for a rare familial form of PD to...