Shridhar Narayanan
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Explore the profile of Shridhar Narayanan including associated specialties, affiliations and a list of published articles.
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59
Citations
678
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Recent Articles
21.
Paul-Satyaseela M, Hariharan P, Bharani T, Franklyne J, Selvakumar T, Bharathimohan K, et al.
J Nat Sci Biol Med
. 2017 Mar;
8(1):119-124.
PMID: 28250687
A set of 12 novel hydroxamate compounds (NHCs), structurally designed as inhibitors of histone deacetylase (HDAC) enzyme, were synthesized at our facility. These were adamantane derivatives with -hydroxyacetamide as pharmacophore,...
22.
Tantry S, Markad S, Shinde V, Bhat J, Balakrishnan G, Gupta A, et al.
J Med Chem
. 2017 Jan;
60(4):1379-1399.
PMID: 28075132
The approval of bedaquiline to treat tuberculosis has validated adenosine triphosphate (ATP) synthase as an attractive target to kill Mycobacterium tuberculosis (Mtb). Herein, we report the discovery of two diverse...
23.
Balasubramanian G, Narayanan S, Andiappan L, Sappanimuthu T, Thirunavukkarasu S, Sundaram S, et al.
Bioorg Med Chem
. 2016 Oct;
24(22):5702-5716.
PMID: 27713015
Herein we report the synthesis, PDE-4B and TNF-α inhibitory activities of a few dibenzo[b,d]furan-1-yl-thiazole derivatives. The hydroxycyclohexanol amide derivatives 14, 18, 24, 29, 31 and 33 exhibited promising in vitro...
24.
Kulkarni N, Malampati S, Mahat M, Chandrasekaran S, Raghul J, Khan A, et al.
Drug Metab Pers Ther
. 2016 Aug;
31(3):165-71.
PMID: 27522101
Background: Severe forms of non-alcoholic fatty liver disease (NAFLD) adversely affect the liver physiology and hence the pharmacokinetics of drugs. Here, we investigated the effect of NAFLD on the pharmacokinetics...
25.
Kaur P, Datta S, Shandil R, Kumar N, Robert N, Sokhi U, et al.
PLoS One
. 2016 May;
11(5):e0154513.
PMID: 27144597
One of the major impediments in anti-tubercular drug discovery is the lack of a robust grammar that governs the in-vitro to the in-vivo translation of efficacy. Mycobacterium tuberculosis (Mtb) is...
26.
Mohan A, Narayanan S, Balasubramanian G, Sethuraman S, Krishnan U
Eur J Pharm Biopharm
. 2015 Dec;
99:73-83.
PMID: 26690333
The rising incidence of head and neck cancer and the drawbacks of currently used therapeutic strategies such as salvage surgery followed by adjuvant chemo- or radiotherapy have encouraged pursuits for...
27.
Kachhadia V, Rajagopal S, Ponpandian T, Vignesh R, Anandhan K, Prabhu D, et al.
Eur J Med Chem
. 2015 Dec;
108:274-286.
PMID: 26689485
Herein we report the synthesis and activity of a novel class of HDAC inhibitors based on 2, 3-diphenyl acrylic acid derivatives. The compounds in this series have shown to be...
28.
Nidhyanandan S, Boreddy T, Chandrasekhar K, Reddy N, Kulkarni N, Narayanan S
Eur J Pharmacol
. 2015 Jul;
764:508-519.
PMID: 26209365
MS-275, a histone deacetylase inhibitor (HDACi), is undergoing clinical trials for treatment of various cancers. Pentoxifylline, a nonselective phosphodiesterase (PDE) inhibitor, has been shown to increase the effectiveness of antitumor...
29.
Sugin Lal Jabaris S, Sumathy H, Girish R, Narayanan S, Sugumar M, Babu C, et al.
Brain Res
. 2015 Jul;
1622:279-91.
PMID: 26168894
Phosphodiesterase-4 (PDE-4) inhibitors promote memory by blocking the degradation of cAMP. Existing evidence also shows that neuronal survival and plasticity are dependent on the phosphorylation of cAMP-response element-binding protein. In...
30.
Singh R, Ramachandran V, Shandil R, Sharma S, Khandelwal S, Karmarkar M, et al.
Antimicrob Agents Chemother
. 2015 Jul;
59(9):5664-74.
PMID: 26149995
There are currently 18 drug classes for the treatment of tuberculosis, including those in the development pipeline. An in silico simulation enabled combing the innumerably large search space to derive...