Shirly Pinto
Overview
Explore the profile of Shirly Pinto including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
44
Citations
2431
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Chitraju C, Mejhert N, Haas J, Diaz-Ramirez L, Grueter C, Imbriglio J, et al.
Cell Metab
. 2017 Aug;
26(2):407-418.e3.
PMID: 28768178
Triglyceride (TG) storage in adipose tissue provides the major reservoir for metabolic energy in mammals. During lipolysis, fatty acids (FAs) are hydrolyzed from adipocyte TG stores and transported to other...
12.
Murphy B, Tadin-Strapps M, Jensen K, Mogg R, Liaw A, Herath K, et al.
Metabolism
. 2017 May;
71:202-212.
PMID: 28521874
Background: SREBP cleavage-activating protein (SCAP) is a cholesterol binding endoplasmic reticulum (ER) membrane protein that is required to activate SREBP transcription factors. SREBPs regulate genes involved in lipid biosynthesis. They...
13.
Identification and characterization of a novel missense mutation associated with congenital diarrhea
Gluchowski N, Chitraju C, Picoraro J, Mejhert N, Pinto S, Xin W, et al.
J Lipid Res
. 2017 Apr;
58(6):1230-1237.
PMID: 28373485
Acyl-CoA:diacylglycerol acyltransferase (DGAT)1 and DGAT2 catalyze triglyceride (TG) biosynthesis in humans. Biallelic loss-of-function mutations in human result in severe congenital diarrhea and protein-losing enteropathy. Additionally, pharmacologic inhibition of DGAT1 led...
14.
Cernak T, Gesmundo N, Dykstra K, Yu Y, Wu Z, Shi Z, et al.
J Med Chem
. 2017 Mar;
60(9):3594-3605.
PMID: 28252959
Miniaturization and parallel processing play an important role in the evolution of many technologies. We demonstrate the application of miniaturized high-throughput experimentation methods to resolve synthetic chemistry challenges on the...
15.
Jensen K, Tadin-Strapps M, Wang S, Hubert J, Kan Y, Ma Y, et al.
J Lipid Res
. 2016 Oct;
57(12):2150-2162.
PMID: 27707816
SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription...
16.
Salowe S, Zhang L, Zokian H, Gesell J, Zink D, Wiltsie J, et al.
J Biomol Screen
. 2016 Jul;
21(10):1034-1041.
PMID: 27412534
PCSK9 plays a significant role in regulating low-density lipoprotein (LDL) cholesterol levels and has become an important drug target for treating hypercholesterolemia. Although a member of the serine protease family,...
17.
Liu J, McLaren D, Chen D, Kan Y, Stout S, Shen X, et al.
Pharmacol Res Perspect
. 2016 Mar;
3(6):e00193.
PMID: 27022467
Studies have demonstrated that blockade of diacylglycerol acyltransferase 1 (DGAT1) leads to prolonged release of glucagon-like peptide 1 (GLP-1) after meal challenge. The current study was undertaken to investigate the...
18.
Imbriglio J, Shen D, Liang R, Marby K, You M, Youm H, et al.
J Med Chem
. 2015 Nov;
58(23):9345-53.
PMID: 26561979
DGAT2 plays a critical role in hepatic triglyceride production, and data suggests that inhibition of DGAT2 could prove to be beneficial in treating a number of disease states. This article...
19.
Song X, Zhang J, Chen X, Palyha O, Chung C, Sonatore L, et al.
J Biomol Screen
. 2015 Sep;
21(2):117-26.
PMID: 26403520
Mass spectrometry offers significant advantages over other detection technologies in the areas of hit finding, hit validation, and medicinal chemistry compound optimization. The foremost obvious advantage is the ability to...
20.
Camus G, Schweiger M, Herker E, Harris C, Kondratowicz A, Tsou C, et al.
J Biol Chem
. 2014 Nov;
289(52):35770-80.
PMID: 25381252
Liver steatosis is a common health problem associated with hepatitis C virus (HCV) and an important risk factor for the development of liver fibrosis and cancer. Steatosis is caused by...