Andreas Verras
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Explore the profile of Andreas Verras including associated specialties, affiliations and a list of published articles.
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35
Citations
295
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Recent Articles
1.
Igawa H, Konst Z, Therrien E, Shelley M, Koldso H, Bos P, et al.
J Med Chem
. 2024 Dec;
67(24):21811-21840.
PMID: 39666597
Despite the success of first, second, and third generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) for non-small cell lung cancer with classical EGFR mutations (L858R or Exon...
2.
Mak V, Patel A, Yen R, Hanisak J, Lim Y, Bao J, et al.
J Med Chem
. 2022 Jul;
65(15):10318-10340.
PMID: 35878399
Activation of PKG1α is a compelling strategy for the treatment of cardiovascular diseases. As the main effector of cyclic guanosine monophosphate (cGMP), activation of PKG1α induces smooth muscle relaxation in...
3.
Lynch E, DiMattia M, Albanese S, van Zundert G, Hansen J, Quispe J, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(40).
PMID: 34583994
Cytidine triphosphate synthase 1 (CTPS1) is necessary for an effective immune response, as revealed by severe immunodeficiency in CTPS1-deficient individuals [E. Martin ], [] [510], [288-292] ([2014]). CTPS1 expression is...
4.
Hanisak J, Soriano A, Adam G, Basso A, Bauman D, Bell D, et al.
ACS Med Chem Lett
. 2021 Aug;
12(8):1275-1282.
PMID: 34413956
PKG1α is a central node in cGMP signaling. Current therapeutics that look to activate this pathway rely on elevation of cGMP levels and subsequent activation of PKG1α. Direct activation of...
5.
Bosc N, Felix E, Arcila R, Mendez D, Saunders M, Green D, et al.
J Cheminform
. 2021 Feb;
13(1):13.
PMID: 33618772
Malaria is a disease affecting hundreds of millions of people across the world, mainly in developing countries and especially in sub-Saharan Africa. It is the cause of hundreds of thousands...
6.
Liu K, Kurukulasuriya R, Dykstra K, DiMichelle L, Liu J, Vachal P, et al.
Bioorg Med Chem Lett
. 2019 May;
29(14):1854-1858.
PMID: 31104995
The derivatization of pharmaceuticals is a core activity in the discovery and development of new medicines. Late-stage functionalization via modern CH functionalization chemistry has emerged as a powerful technique with...
7.
Yu Y, Wu Z, Shi Z, He S, Lai Z, Cernak T, et al.
Bioorg Med Chem Lett
. 2019 Apr;
29(11):1380-1385.
PMID: 30952592
The parallel medicinal chemistry (PMC) was effectively applied to accelerate the optimization of diacylglycerol O-acyltransferase I (DGAT-1) inhibitors. Through a highly collaborative and iterative library design, synthesis and testing, a...
8.
He S, Lai Z, Hong Q, Shang J, Reibarkh M, Kuethe J, et al.
Bioorg Med Chem Lett
. 2019 Mar;
29(10):1182-1186.
PMID: 30926247
Previously disclosed benzimidazole-based DGAT1 inhibitors containing a cyclohexane carboxylic acid moiety suffer from isomerization at the alpha position of the carboxylic acid group, generating active metabolites which exhibit DGAT1 inhibition...
9.
Gao Y, Hu Y, Crespo A, Wang D, Armacost K, Fells J, et al.
J Comput Aided Mol Des
. 2017 Oct;
32(1):129-142.
PMID: 28986733
The 2016 D3R Grand Challenge 2 includes both pose and affinity or ranking predictions. This article is focused exclusively on affinity predictions submitted to the D3R challenge from a collaborative...
10.
Fradera X, Verras A, Hu Y, Wang D, Wang H, Fells J, et al.
J Comput Aided Mol Des
. 2017 Sep;
32(1):113-127.
PMID: 28913710
We describe the performance of multiple pose prediction methods for the D3R 2016 Grand Challenge. The pose prediction challenge includes 36 ligands, which represent 4 chemotypes and some miscellaneous structures...