Shinya Hanashima
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Explore the profile of Shinya Hanashima including associated specialties, affiliations and a list of published articles.
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83
Citations
679
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Recent Articles
1.
Yasuda T, Ueura D, Nakagomi M, Hanashima S, Murata M
Biophys Chem
. 2025 Mar;
322:107433.
PMID: 40080927
Ceramide 1-phosphate (C1P), as a lipid mediator, specifically binds and activates cytosolic phospholipase Aα (cPLAα). Previous findings revealed that modification of the specific hydrophobic moiety decreases the affinity with cPLAα....
2.
Hanashima S, Yamanaka A, Ibata Y, Yasuda T, Umegawa Y, Murata M
Langmuir
. 2024 Oct;
40(43):22973-22981.
PMID: 39429033
Sphingomyelin (SM) and cholesterol are the major lipids in the signaling platforms of cell membranes, known as lipid rafts. In particular, SM with a stearoyl chain (C18-SM) is abundant in...
3.
Garza-Miyazato D, Hanashima S, Umegawa Y, Murata M, Kinoshita M, Matsumori N, et al.
Biochim Biophys Acta Biomembr
. 2024 Jul;
1866(7):184366.
PMID: 38960300
Ginsenoside Rh2 (Rh2) is a ginseng saponin comprising a triterpene core and one unit of glucose and has attracted much attention due to its diverse biological activities. In the present...
4.
Yasuda T, Ueura D, Nakagomi M, Hanashima S, Peter Slotte J, Murata M
Bioorg Med Chem Lett
. 2024 May;
107:129792.
PMID: 38734389
Ceramide 1-phosphate (C1P) is a lipid mediator that specifically binds and activates cytosolic phospholipase Aα (cPLAα). To elucidate the structure-activity relationship of the affinity of C1P for cPLAα in lipid...
5.
Watanabe H, Hanashima S, Yano Y, Yasuda T, Murata M
Langmuir
. 2023 Sep;
39(43):15189-15199.
PMID: 37729012
Although lateral and inter-leaflet lipid-lipid interactions in cell membranes play roles in maintaining asymmetric lipid bilayers, the molecular basis of these interactions is largely unknown. Here, we established a method...
6.
Effect of the number of sugar units on the interaction between diosgenyl saponin and membrane lipids
Ondevilla J, Hanashima S, Mukogawa A, Miyazato D, Umegawa Y, Murata M
Biochim Biophys Acta Biomembr
. 2023 Mar;
1865(5):184145.
PMID: 36914020
Saponin is the main bioactive component of the Dioscorea species, which are traditionally used for treating chronic diseases. An understanding of the interaction process of bioactive saponins with biomembranes provides...
7.
Yasuda T, Peter Slotte J, Murata M, Hanashima S
Methods Mol Biol
. 2022 Dec;
2613:257-270.
PMID: 36587084
Glycosphingolipids (GSLs) in the mammalian plasma membrane are essential for various biological events as they form glycolipid-rich membrane domains, such as lipid rafts. GSLs consist of a certain oligosaccharide head...
8.
Yasuda T, Watanabe H, Hirosawa K, Suzuki K, Suga K, Hanashima S
Langmuir
. 2022 Nov;
38(48):14695-14703.
PMID: 36421004
Exosomes are small extracellular vesicles (sEVs) involved in distal cell-cell communication and cancer migration by transferring functional cargo molecules. Membrane domains similar to lipid rafts are assumed to occur in...
9.
Garza D, Hanashima S, Umegawa Y, Murata M, Kinoshita M, Matsumori N, et al.
Langmuir
. 2022 Aug;
38(34):10478-10491.
PMID: 35984899
The ginsenoside Rh2 (Rh2) is a saponin of medicinal ginseng, and it has attracted much attention for its pharmacological activities. In this study, we investigated the interaction of Rh2 with...
10.
Hanashima S, Mito K, Umegawa Y, Murata M, Hojo H
Org Biomol Chem
. 2022 Jul;
20(32):6436-6444.
PMID: 35880995
-Myristoylation is a process of ubiquitous protein modification, which promotes the interaction of lipidated proteins on cell surfaces, in conjunction with reversible -palmitoylation. We report the cooperative lipid-lipid interaction of...