Sherif E Gabriel
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Explore the profile of Sherif E Gabriel including associated specialties, affiliations and a list of published articles.
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11
Citations
593
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Recent Articles
1.
Clancy J, Szczesniak R, Ashlock M, Ernst S, Fan L, Hornick D, et al.
PLoS One
. 2013 Sep;
8(9):e73905.
PMID: 24040112
Intestinal current measurements (ICM) from rectal biopsies are a sensitive means to detect cystic fibrosis transmembrane conductance regulator (CFTR) function, but have not been optimized for multicenter use. We piloted...
2.
Sheridan J, Worthington E, Yu K, Gabriel S, Hartzell H, Tarran R
J Biol Chem
. 2010 Nov;
286(2):1381-8.
PMID: 21056985
Members of the Anoctamin (Ano)/TMEM16A family have recently been identified as essential subunits of the Ca(2+)-activated chloride channel (CaCC). For example, Ano1 is highly expressed in multiple tissues including airway...
3.
Zhang L, Button B, Gabriel S, Burkett S, Yan Y, Skiadopoulos M, et al.
PLoS Biol
. 2009 Jul;
7(7):e1000155.
PMID: 19621064
Dysfunction of CFTR in cystic fibrosis (CF) airway epithelium perturbs the normal regulation of ion transport, leading to a reduced volume of airway surface liquid (ASL), mucus dehydration, decreased mucus...
4.
Rock J, ONeal W, Gabriel S, Randell S, Harfe B, Boucher R, et al.
J Biol Chem
. 2009 Apr;
284(22):14875-80.
PMID: 19363029
For almost two decades, it has been postulated that calcium-activated Cl(-) channels (CaCCs) play a role in airway epithelial Cl(-) secretion, but until recently, the molecular identity of the airway...
5.
Yang L, Reece J, Gabriel S, Shears S
J Cell Sci
. 2006 Mar;
119(Pt 7):1320-8.
PMID: 16537650
A new aspect of research into the pathogenesis of cystic fibrosis (CF) is a genetics-based search for ;modifier genes' that may affect the severity of CF lung disease. Using an...
6.
Grubb B, Gabriel S, Mengos A, Gentzsch M, Randell S, van Heeckeren A, et al.
Am J Respir Cell Mol Biol
. 2005 Nov;
34(3):355-63.
PMID: 16284361
Deletion of phenylalanine 508 (deltaF508) accounts for nearly 70% of all mutations that occur in the cystic fibrosis transmembrane conductance regulator (CFTR). The deltaF508 mutation is a class II processing...
7.
Loewen M, Bekar L, Walz W, Forsyth G, Gabriel S
Am J Physiol Gastrointest Liver Physiol
. 2004 Feb;
287(1):G33-41.
PMID: 14988065
The effects of CLCA protein expression on the regulation of Cl(-) conductance by intracellular Ca(2+) and cAMP have been studied previously in nonepithelial cell lines chosen for low backgrounds of...
8.
Loewen M, Bekar L, Gabriel S, Walz W, Forsyth G
Biochem Biophys Res Commun
. 2002 Nov;
298(4):531-6.
PMID: 12408984
Members of the CLCA protein family are expressed in airway and intestinal epithelium, where they may participate in secretory activity as mediators of chloride conductance. A calcium-dependent chloride conductance has...
9.
Tarran R, Loewen M, Paradiso A, Olsen J, Gray M, Argent B, et al.
J Gen Physiol
. 2002 Aug;
120(3):407-18.
PMID: 12198094
Two Cl(-) conductances have been described in the apical membrane of both human and murine proximal airway epithelia that are thought to play predominant roles in airway hydration: (1) CFTR,...
10.
Loewen M, Gabriel S, Forsyth G
Am J Physiol Cell Physiol
. 2002 Jul;
283(2):C412-21.
PMID: 12107050
The regulatory behavior, inhibitor sensitivity, and properties of the whole cell chloride conductance observed in cells expressing the cDNA coding for a chloride conductance mediator isoform of the CLCA gene...