Robert K Andrews
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Explore the profile of Robert K Andrews including associated specialties, affiliations and a list of published articles.
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131
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2307
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Recent Articles
1.
Hyslop S, Corbin J, Gangatirkar P, Lebois M, Au A, Moujalled D, et al.
J Thromb Haemost
. 2025 Mar;
PMID: 40056985
Background: Newly produced platelets are thought to be more functional than their older counterparts. However, recent work suggests that murine platelets formed following immune thrombocytopenia possess a transient glycoprotein VI...
2.
Brysland S, Talaulikar D, Hicks S, Hearn J, Ali S, Maqbool M, et al.
Blood Adv
. 2024 Aug;
8(21):5542-5555.
PMID: 39207869
Clinical features in patients with the B-cell lymphoma, Waldenström macroglobulinemia (WM), include cytopenias, immunoglobulin M (IgM)-mediated hyperviscosity, fatigue, bleeding, and bruising. Therapeutics such as Bruton's tyrosine kinase inhibitors (BTKis) exacerbate...
3.
Sun Y, Tong H, Chu X, Li Y, Zhang J, Ding Y, et al.
Blood
. 2024 Apr;
143(26):2778-2790.
PMID: 38603632
Notch signaling regulates cell-fate decisions in several developmental processes and cell functions. However, the role of Notch in hepatic thrombopoietin (TPO) production remains unclear. We noted thrombocytopenia in mice with...
4.
Lee C, Kaur A, Montague S, Hicks S, Andrews R, Gardiner E
Platelets
. 2023 Nov;
34(1):2288213.
PMID: 38031964
Platelet-specific collagen receptor glycoprotein (GP)VI is stable on the surface of circulating platelets but undergoes ectodomain cleavage on activated platelets. Activation-dependent GPVI metalloproteolysis is primarily mediated by A Disintegrin And...
5.
Ding Y, Gui X, Chu X, Sun Y, Zhang S, Tong H, et al.
Nat Commun
. 2023 Aug;
14(1):4829.
PMID: 37563135
Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative stress. Expression and functional roles of MTH1...
6.
Wang X, Wei G, Ding Y, Gui X, Tong H, Xu X, et al.
Blood
. 2022 Jun;
140(9):1038-1051.
PMID: 35767715
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) is a protein tyrosine phosphatase that negatively regulates T-cell signaling. However, whether it is expressed and functions in platelets remains unknown. Here we...
7.
Wines B, Trist H, Esparon S, Impey R, Mackay G, Andrews R, et al.
Front Immunol
. 2021 Nov;
12:666813.
PMID: 34759915
FcγR activity underpins the role of antibodies in both protective immunity and auto-immunity and importantly, the therapeutic activity of many monoclonal antibody therapies. Some monoclonal anti-FcγR antibodies activate their receptors,...
8.
Walsh T, Li Y, Williams C, Aitken E, Andrews R, Poole A
Blood Adv
. 2021 Feb;
5(3):674-686.
PMID: 33560379
The exocyst is an octameric complex comprising 8 distinct protein subunits, exocyst complex components (EXOC) 1 to 8. It has an established role in tethering secretory vesicles to the plasma...
9.
Pallini C, Pike J, OShea C, Andrews R, Gardiner E, Watson S, et al.
Platelets
. 2021 Jan;
32(1):59-73.
PMID: 33455536
Collagen, the most thrombogenic constituent of blood vessel walls, activates platelets through glycoprotein VI (GPVI). In suspension, following platelet activation by collagen, GPVI is cleaved by A Disintegrin And Metalloproteinase...
10.
Barrachina M, Hermida-Nogueira L, Moran L, Casas V, Hicks S, Sueiro A, et al.
Arterioscler Thromb Vasc Biol
. 2020 Nov;
41(1):478-490.
PMID: 33147989
Objective: Obesity is associated with a proinflammatory and prothrombotic state that supports atherosclerosis progression. The goal of this study was to gain insights into the phosphorylation events related to platelet...