Shaun OBrien
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Explore the profile of Shaun OBrien including associated specialties, affiliations and a list of published articles.
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28
Citations
2688
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Recent Articles
1.
Nelson B, OBrien S, Sheth R, Hong D, Naing A, Zhang X, et al.
J Immunother Cancer
. 2025 Jan;
13(1.
PMID: 39824531
Purpose: BMS-986299 is a first-in-class, NOD-, LRR-, and pyrin-domain containing-3 (NLRP3) inflammasome agonist enhancing adaptive immune and T-cell memory responses. Materials And Methods: This was a phase-I (NCT03444753) study that...
2.
Callahan M, Amin A, Kaye F, Morse M, Taylor M, Peltola K, et al.
J Immunother Cancer
. 2024 Feb;
12(2).
PMID: 38316517
Background: Pancreatic cancer is one of the deadliest cancer types and represents a major unmet medical need. CheckMate 032 investigated safety and efficacy of nivolumab monotherapy and nivolumab plus ipilimumab...
3.
Snow M, Middleton L, Mehta S, Roberts A, Gray R, Richardson J, et al.
Am J Sports Med
. 2023 Jan;
51(2):367-378.
PMID: 36661257
Background: There are limited randomized controlled trials with long-term outcomes comparing autologous chondrocyte implantation (ACI) versus alternative forms of surgical cartilage management within the knee. Purpose: To determine at 5...
4.
Garabadi M, OBrien S
Trauma Case Rep
. 2021 Aug;
35:100512.
PMID: 34377759
Hardware breakage during orthopaedic surgery especially closed intramedullary nailing is a nightmare for orthopaedic surgeons. During hip fracture surgery a mechanical failure of the guidewire or the reamer poses an...
5.
Geuijen C, Tacken P, Wang L, Klooster R, van Loo P, Zhou J, et al.
Nat Commun
. 2021 Jul;
12(1):4445.
PMID: 34290245
Immune checkpoint inhibitors demonstrate clinical activity in many tumor types, however, only a fraction of patients benefit. Combining CD137 agonists with these inhibitors increases anti-tumor activity preclinically, but attempts to...
6.
Martinez M, Kim S, St Jean N, OBrien S, Lian L, Sun J, et al.
Oncoimmunology
. 2021 Feb;
10(1):1873607.
PMID: 33537176
PD1 blockade to reinvigorate T cells has become part of standard of care for patients with NSCLC across disease stages. However, the majority of patients still do not respond. One...
7.
Predina J, Haas A, Martinez M, OBrien S, Moon E, Woodruff P, et al.
Mol Ther
. 2020 Nov;
29(2):658-670.
PMID: 33160076
Gene-mediated cytotoxic immunotherapy (GMCI) is an immuno-oncology approach involving local delivery of a replication-deficient adenovirus expressing herpes simplex thymidine kinase (AdV-tk) followed by anti-herpetic prodrug activation that promotes immunogenic tumor...
8.
Singhal S, Stadanlick J, Annunziata M, Rao A, Bhojnagarwala P, OBrien S, et al.
Sci Transl Med
. 2019 Feb;
11(479).
PMID: 30760579
Data from mouse tumor models suggest that tumor-associated monocyte/macrophage lineage cells (MMLCs) dampen antitumor immune responses. However, given the fundamental differences between mice and humans in tumor evolution, genetic heterogeneity,...
9.
Bengsch B, Ohtani T, Khan O, Setty M, Manne S, OBrien S, et al.
Immunity
. 2018 May;
48(5):1029-1045.e5.
PMID: 29768164
Exhausted CD8 T (Tex) cells are immunotherapy targets in chronic infection and cancer, but a comprehensive assessment of Tex cell diversity in human disease is lacking. Here, we developed a...
10.
Newick K, OBrien S, Moon E, Albelda S
Annu Rev Med
. 2016 Nov;
68:139-152.
PMID: 27860544
The field of cancer immunotherapy has been re-energized by the application of chimeric antigen receptor (CAR) T cell therapy in cancers. These CAR T cells are engineered to express synthetic...