Wayne W Hancock
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Explore the profile of Wayne W Hancock including associated specialties, affiliations and a list of published articles.
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165
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7665
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Recent Articles
1.
Yardeni T, Olali A, Chen H, Wang L, Halton J, Zenab A, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2417252121.
PMID: 39752523
Mitochondrial DNA (mtDNA) is highly polymorphic, and host mtDNA variation has been associated with altered cancer severity. To determine the basis of this mtDNA-cancer association, we analyzed conplastic mice with...
2.
Akimova T, Wang L, Bartosh Z, Christensen L, Eruslanov E, Singhal S, et al.
Front Immunol
. 2024 Sep;
15:1426657.
PMID: 39234236
Our goal is to improve the outcomes of cancer immunotherapy by targeting FOXP3+ T-regulatory (Treg) cells with a next generation of antisense oligonucleotides (ASO), termed FOXP3 AUMsilence ASO. We performed...
3.
Christensen L, Akimova T, Wang L, Han R, Samanta A, Di Giorgio E, et al.
Front Immunol
. 2024 Aug;
15:1444937.
PMID: 39156895
Histone deacetylases 1 and 2 play a major role in the transcriptional regulation of T-regulatory (Treg) cells via interactions with a myriad of coregulatory factors. Sin3a has been well established...
4.
Concors S, Hernandez P, OBrien C, DePaolo J, Murken D, Aufhauser D, et al.
Transplantation
. 2024 Apr;
108(10):2084-2092.
PMID: 38685198
Background: Ischemia-reperfusion injury (IRI) causes significant morbidity in liver transplantation among other medical conditions. IRI following liver transplantation contributes to poor outcomes and early graft loss. Histone/protein deacetylases (HDACs) regulate...
5.
Thomas R, Pahl M, Wang L, Grant S, Hancock W, Wells A
Elife
. 2024 Apr;
12.
PMID: 38655862
Ikaros is a transcriptional factor required for conventional T cell development, differentiation, and anergy. While the related factors Helios and Eos have defined roles in regulatory T cells (Treg), a...
6.
Cravedi P, Riella L, Ford M, Valujskikh A, Menon M, Kirk A, et al.
Am J Transplant
. 2024 Jan;
24(8):1362-1368.
PMID: 38219866
Mouse models have been instrumental in understanding mechanisms of transplant rejection and tolerance, but cross-study reproducibility and translation of experimental findings into effective clinical therapies are issues of concern. The...
7.
Patterson K, Miller W, Hancock W, Akimova T
Front Immunol
. 2024 Jan;
14:1301991.
PMID: 38173720
Rationale: Sarcoidosis is an inflammatory granulomatous disease of unknown etiology with predominant lung involvement. Organ involvement and disease severity, as well as the nature of immune alterations, vary among patients...
8.
Lax E, Do Carmo S, Enuka Y, Sapozhnikov D, Welikovitch L, Mahmood N, et al.
Transl Psychiatry
. 2023 Jul;
13(1):259.
PMID: 37443311
The Methyl-CpG-Binding Domain Protein family has been implicated in neurodevelopmental disorders. The Methyl-CpG-binding domain 2 (Mbd2) binds methylated DNA and was shown to play an important role in cancer and...
9.
Christensen L, Hancock W
Front Immunol
. 2022 Jul;
13:909816.
PMID: 35795673
T-regulatory (Treg) cells display considerable heterogeneity in their responses to various cancers. The functional differences among this cell type are heavily influenced by multiprotein nuclear complexes that control their gene...
10.
Hernandez P, OBrien C, Concors S, Wang Z, Ge G, Hancock W, et al.
Transplantation
. 2022 Jun;
106(11):2166-2171.
PMID: 35655356
Background: There is increasing evidence that estrogen is responsible for improved outcomes in female kidney transplant recipients. Although the exact mechanism is not yet known, estrogen appears to exert its...