Shashank Pant
Overview
Explore the profile of Shashank Pant including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
330
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Recent Articles
1.
Zhang Y, Soubias O, Pant S, Heinrich F, Vogel A, Li J, et al.
Nat Commun
. 2023 Nov;
14(1):7570.
PMID: 37989735
ADP-ribosylation factor 1 (Arf1) interacts with multiple cellular partners and membranes to regulate intracellular traffic, organelle structure and actin dynamics. Defining the dynamic conformational landscape of Arf1 in its active...
2.
Le L, Thompson J, Dehghani-Ghahnaviyeh S, Pant S, Dang P, French J, et al.
EMBO J
. 2022 Dec;
42(3):e111065.
PMID: 36484366
Phospholipid extrusion by ABC subfamily A (ABCA) exporters is central to cellular physiology, although the specifics of the underlying substrate interactions and transport mechanisms remain poorly resolved at the molecular...
3.
Singaram I, Sharma A, Pant S, Lihan M, Park M, Pergande M, et al.
Nat Chem Biol
. 2022 Oct;
19(2):239-250.
PMID: 36229686
Membrane lipids control the cellular activity of kinases containing the Src homology 2 (SH2) domain through direct lipid-SH2 domain interactions. Here we report development of new nonlipidic small molecule inhibitors...
4.
Mehdi S, Wang D, Pant S, Tiwary P
J Chem Theory Comput
. 2022 Apr;
18(5):3231-3238.
PMID: 35384668
An effective implementation of enhanced sampling algorithms for molecular dynamics simulations requires knowledge of the approximate reaction coordinate describing the relevant mechanisms in the system. In this work, we focus...
5.
Pant S, Wu Q, Ryan R, Tajkhorshid E
ACS Chem Neurosci
. 2022 Feb;
13(6):776-785.
PMID: 35192345
Excitatory amino acid transporters (EAATs) are glutamate transporters that belong to the solute carrier 1A (SLC1A) family. They couple glutamate transport to the cotransport of three sodium (Na) ions and...
6.
Wu Q, Akhter A, Pant S, Cho E, Zhu J, Garner A, et al.
J Clin Invest
. 2022 Feb;
132(7).
PMID: 35167492
Glutamate is the predominant excitatory neurotransmitter in the mammalian central nervous system (CNS). Excitatory amino acid transporters (EAATs) regulate extracellular glutamate by transporting it into cells, mostly glia, to terminate...
7.
Chen H, Ogden D, Pant S, Cai W, Tajkhorshid E, Moradi M, et al.
J Chem Theory Comput
. 2022 Feb;
18(3):1406-1422.
PMID: 35138832
The string method with swarms of trajectories (SMwST) is an algorithm that identifies a physically meaningful transition pathway─a one-dimensional curve, embedded within a high-dimensional space of selected collective variables. The...
8.
Gullett J, Cuypers M, Grace C, Pant S, Subramanian C, Tajkhorshid E, et al.
J Biol Chem
. 2022 Feb;
298(3):101676.
PMID: 35122790
Fatty acid (FA) transfer proteins extract FA from membranes and sequester them to facilitate their movement through the cytosol. Detailed structural information is available for these soluble protein-FA complexes, but...
9.
Pant S, Zhang J, Chang Kim E, Lam K, Chung H, Tajkhorshid E
Commun Biol
. 2021 Oct;
4(1):1189.
PMID: 34650221
Phosphatidylinositol-4,5-bisphosphate (PIP) is a signaling lipid which regulates voltage-gated K7/KCNQ potassium channels. Altered PIP sensitivity of neuronal K7.2 channel is involved in KCNQ2 epileptic encephalopathy. However, the molecular action of...
10.
Kapoor K, Pant S, Tajkhorshid E
Chem Sci
. 2021 Jun;
12(18):6293-6306.
PMID: 34084427
P-glycoprotein (Pgp) is a major efflux pump in humans, overexpressed in a variety of cancers and associated with the development of multi-drug resistance. Allosteric modulation by various ligands (, transport...