Paul A Randazzo
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Explore the profile of Paul A Randazzo including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Soubias O, Foley S, Jian X, Jackson R, Zhang Y, Rosenberg E, et al.
bioRxiv
. 2025 Jan;
PMID: 39763923
ASAP1 is a multidomain Arf GTPase-activating protein (ArfGAP) that catalyzes GTP hydrolysis on the small GTPase Arf1 and is implicated in cancer progression. The PH domain of ASAP1 enhances its...
2.
Hebron K, Perkins O, Kim A, Jian X, Girald-Berlingeri S, Lei H, et al.
Mol Cancer Res
. 2024 Nov;
23(2):95-106.
PMID: 39495123
Despite aggressive, multimodal therapies, the prognosis of patients with refractory or recurrent rhabdomyosarcoma (RMS) has not improved in four decades. Because RMS resembles skeletal muscle precursor cells, differentiation-inducing therapy has...
3.
Hammoudeh S, Ng Y, Wei B, Madsen T, Yadav M, Simpson R, et al.
Cell Rep Methods
. 2024 Jul;
4(7):100802.
PMID: 38964316
PAX3/7 fusion-negative rhabdomyosarcoma (FN-RMS) is a childhood mesodermal lineage malignancy with a poor prognosis for metastatic or relapsed cases. Limited understanding of advanced FN-RMS is partially attributed to the absence...
4.
Rosenberg Jr E, Jian X, Soubias O, Jackson R, Gladu E, Andersen E, et al.
PLoS One
. 2024 Apr;
19(4):e0295103.
PMID: 38574162
The ADP-ribosylation factors (Arfs) constitute a family of small GTPases within the Ras superfamily, with a distinguishing structural feature of a hypervariable N-terminal extension of the G domain modified with...
5.
Hammoudeh S, Ng Y, Wei B, Madsen T, Simpson R, Weigert R, et al.
bioRxiv
. 2023 Dec;
PMID: 38076999
PAX3/7 Fusion-negative rhabdomyosarcoma (FN-RMS) is a childhood mesodermal lineage malignancy with a poor prognosis for metastatic or relapsed cases. Towards achieving a more complete understanding of advanced FN-RMS, we developed...
6.
Zhang Y, Soubias O, Pant S, Heinrich F, Vogel A, Li J, et al.
Nat Commun
. 2023 Nov;
14(1):7570.
PMID: 37989735
ADP-ribosylation factor 1 (Arf1) interacts with multiple cellular partners and membranes to regulate intracellular traffic, organelle structure and actin dynamics. Defining the dynamic conformational landscape of Arf1 in its active...
7.
Rosenberg Jr E, Jian X, Soubias O, Yoon H, Yadav M, Hammoudeh S, et al.
J Biol Chem
. 2023 Feb;
299(3):102992.
PMID: 36758799
The ADP-ribosylation factor (Arf) GTPases and their regulatory proteins are implicated in cancer progression. NAV-2729 was previously identified as a specific inhibitor of Arf6 that reduced progression of uveal melanoma...
8.
Gasilina A, Randazzo P
Bio Protoc
. 2022 Oct;
12(18).
PMID: 36311348
Understanding the molecular and structural mechanisms that govern the assembly and organization of higher-order actin architecture requires the use of actin binding and bundling assays. Crosslinking of actin filaments into...
9.
Yoon H, Maron B, Girald-Berlingeri S, Gasilina A, Gollin J, Jian X, et al.
Biochim Biophys Acta Mol Cell Res
. 2022 Apr;
1869(8):119264.
PMID: 35381293
Osteosarcoma (OS) and Pax-Foxo1 fusion negative rhabdomyosarcoma (FN-RMS) are pediatric sarcomas with poor prognoses in patients with advanced disease. In both malignancies, an actin binding protein has been linked to...
10.
Gasilina A, Yoon H, Jian X, Luo R, Randazzo P
J Biol Chem
. 2022 Feb;
298(3):101700.
PMID: 35143843
Actin filament maintenance is critical for both normal cell homeostasis and events associated with malignant transformation. The ADP-ribosylation factor GTPase-activating protein ASAP1 regulates the dynamics of filamentous actin-based structures, including...