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Frank Heinrich

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Articles 64
Citations 1115
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Recent Articles
1.
Heinrich F, Nagle J
Soft Matter . 2025 Feb; PMID: 39992286
The effect of cholesterol on the bending modulus of DOPC lipid bilayers has been controversial. Previous analysis of dynamic neutron spin echo (NSE) data reported that 50% cholesterol increased by...
2.
Hoogerheide D, Heinrich F
J Appl Crystallogr . 2025 Jan; 57(4). PMID: 39872916
Neutron reflectometry (NR) is a powerful technique for interrogating the structure of thin films at interfaces. Because NR measurements are slow and instrument availability is limited, measurement efficiency is paramount....
3.
Soubias O, Foley S, Jian X, Jackson R, Zhang Y, Rosenberg Jr E, et al.
bioRxiv . 2025 Jan; PMID: 39763923
ASAP1 is a multidomain Arf GTPase-activating protein (ArfGAP) that catalyzes GTP hydrolysis on the small GTPase Arf1 and is implicated in cancer progression. The PH domain of ASAP1 enhances its...
4.
Mitra S, Chen M, Stedman F, Hernandez J, Kumble G, Kang X, et al.
J Phys Chem B . 2024 Sep; 128(40):9772-9784. PMID: 39328031
This study investigates the potential of antimicrobial peptides (AMPs) as alternatives to combat antibiotic resistance, with a focus on two AMPs containing unnatural amino acids (UAAs), E2-53R (16 AAs) and...
5.
Mitra S, Chandersekhar B, Li Y, Coopershlyak M, Mahoney M, Evans B, et al.
Soft Matter . 2024 May; 20(20):4088-4101. PMID: 38712559
This research addresses the growing menace of antibiotic resistance by exploring antimicrobial peptides (AMPs) as alternatives to conventional antibiotics. Specifically, we investigate two linear amphipathic AMPs, LE-53 (12-mer) and LE-55...
6.
Jakkampudi T, Lin Q, Mitra S, Vijai A, Qin W, Kang A, et al.
Biomacromolecules . 2024 Apr; 25(5):3215. PMID: 38640499
No abstract available.
7.
Zhang Y, Soubias O, Pant S, Heinrich F, Vogel A, Li J, et al.
Nat Commun . 2023 Nov; 14(1):7570. PMID: 37989735
ADP-ribosylation factor 1 (Arf1) interacts with multiple cellular partners and membranes to regulate intracellular traffic, organelle structure and actin dynamics. Defining the dynamic conformational landscape of Arf1 in its active...
8.
Mitra S, Coopershlyak M, Li Y, Chandersekhar B, Koenig R, Chen M, et al.
Adv Nanobiomed Res . 2023 Jul; 3(5). PMID: 37476397
Antibiotics are losing effectiveness as bacteria become resistant to conventional drugs. To find new alternatives, antimicrobial peptides (AMPs) are rationally designed with different lengths, charges, hydrophobicities (), and hydrophobic moments...
9.
Jakkampudi T, Lin Q, Mitra S, Vijai A, Qin W, Kang A, et al.
Biomacromolecules . 2023 May; 24(6):2804-2815. PMID: 37223955
SPLUNC1 (short palate lung and nasal epithelial clone 1) is a multifunctional host defense protein found in human respiratory tract with antimicrobial properties. In this work, we compare the biological...
10.
Heinrich F, Thomas C, Alvarado J, Eells R, Thomas A, Doucet M, et al.
J Mol Biol . 2023 Feb; 435(8):168009. PMID: 36773691
The HIV-1 Nef protein plays a critical role in viral infectivity, high-titer replication in vivo, and immune escape of HIV-infected cells. Nef lacks intrinsic biochemical activity, functioning instead through interactions...